Aaron C Groen
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Explore the profile of Aaron C Groen including associated specialties, affiliations and a list of published articles.
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26
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1264
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Recent Articles
11.
Coughlin M, Groen A, Mitchison T
Methods Mol Biol
. 2013 Dec;
1117:259-71.
PMID: 24357367
Cell-free cytoplasm isolated from meiotic Xenopus egg extracts reconstitutes microtubule phenomena in vitro. These crude extracts assemble bipolar meiotic spindles and are readily fractionated for biochemical assays, providing a good...
12.
Mitchison T, Nguyen P, Coughlin M, Groen A
Mol Biol Cell
. 2013 Mar;
24(10):1559-73.
PMID: 23515222
Previous study of self-organization of Taxol-stabilized microtubules into asters in Xenopus meiotic extracts revealed motor-dependent organizational mechanisms in the spindle. We revisit this approach using clarified cytosol with glycogen added...
13.
Petry S, Groen A, Ishihara K, Mitchison T, Vale R
Cell
. 2013 Feb;
152(4):768-77.
PMID: 23415226
The microtubules that comprise mitotic spindles in animal cells are nucleated at centrosomes and by spindle assembly factors that are activated in the vicinity of chromatin. Indirect evidence has suggested...
14.
Groen A, Coughlin M, Mitchison T
Mol Biol Cell
. 2011 Jul;
22(17):3139-51.
PMID: 21737678
The assembly of microtubules during mitosis requires many identified components, such as γ-tubulin ring complex (γ-TuRC), components of the Ran pathway (e.g., TPX2, HuRP, and Rae1), and XMAP215/chTOG. However, it...
15.
Maresca T, Groen A, Gatlin J, Ohi R, Mitchison T, Salmon E
Curr Biol
. 2009 Jun;
19(14):1210-5.
PMID: 19540121
During animal cell division, a gradient of GTP-bound Ran is generated around mitotic chromatin. It is generally accepted that this RanGTP gradient is essential for organizing the spindle, because it...
16.
Groen A, Maresca T, Gatlin J, Salmon E, Mitchison T
Mol Biol Cell
. 2009 Apr;
20(11):2766-73.
PMID: 19369413
Distinct pathways from centrosomes and chromatin are thought to contribute in parallel to microtubule nucleation and stabilization during animal cell mitotic spindle assembly, but their full mechanisms are not known....
17.
Wuhr M, Dumont S, Groen A, Needleman D, Mitchison T
Cell Cycle
. 2009 Mar;
8(8):1115-21.
PMID: 19282671
Microtubules play a central role in centering the nucleus or mitotic spindle in eukaryotic cells. However, despite common use of microtubules for centering, physical mechanisms can vary greatly, and depend...
18.
Gatlin J, Matov A, Groen A, Needleman D, Maresca T, Danuser G, et al.
Curr Biol
. 2009 Feb;
19(4):287-96.
PMID: 19230671
Background: Bipolar spindle assembly is critical for achieving accurate segregation of chromosomes. In the absence of centrosomes, meiotic spindles achieve bipolarity by a combination of chromosome-initiated microtubule nucleation and stabilization...
19.
Wuhr M, Chen Y, Dumont S, Groen A, Needleman D, Salic A, et al.
Curr Biol
. 2008 Aug;
18(16):1256-61.
PMID: 18718761
Size specification of macromolecular assemblies in the cytoplasm is poorly understood [1]. In principle, assemblies could scale with cell size or use intrinsic mechanisms. For the mitotic spindle, scaling with...
20.
Groen A, Needleman D, Brangwynne C, Gradinaru C, Fowler B, Mazitschek R, et al.
J Cell Sci
. 2008 Jun;
121(Pt 14):2293-300.
PMID: 18559893
The tetrameric plus-end-directed motor, kinesin-5, is essential for bipolar spindle assembly. Small-molecule inhibitors of kinesin-5 have been important tools for investigating its function, and some are currently under evaluation as...