A W Wolkoff
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Explore the profile of A W Wolkoff including associated specialties, affiliations and a list of published articles.
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94
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1252
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Recent Articles
1.
Brazhnik K, Sun S, Alani O, Kinkhabwala M, Wolkoff A, Maslov A, et al.
Sci Adv
. 2020 Feb;
6(5):eaax2659.
PMID: 32064334
Accumulating somatic mutations have been implicated in age-related cellular degeneration and death. Because of their random nature and low abundance, somatic mutations are difficult to detect except in single cells...
2.
3.
Wijetunga N, Pascual M, Tozour J, Delahaye F, Alani M, Adeyeye M, et al.
Oncogene
. 2016 Oct;
36(14):2030-2044.
PMID: 27721404
The predisposition of patients with Hepatitis C virus (HCV) infection to hepatocellular carcinoma (HCC) involves components of viral infection, inflammation and time. The development of multifocal, genetically distinct tumours is...
4.
Stockert R, Wolkoff A
Curr Opin Gastroenterol
. 2006 Oct;
17(3):205-10.
PMID: 17031161
Recently, several lines of investigation focused on basic mechanisms governing cellular and molecular aspects of liver biology have intersected at the study of the hepatic stem cell. Despite years of...
5.
Shi X, Potvin B, Huang T, Hilgard P, Spray D, Suadicani S, et al.
J Biol Chem
. 2000 Oct;
276(3):2075-82.
PMID: 11038365
A previously isolated endocytic trafficking mutant (TRF1) isolated from HuH-7 cells is defective in the distribution of subpopulations of cell-surface receptors for asialoorosomucoid (asialoglycoprotein receptor (ASGR)), transferrin, and mannose-terminating glycoproteins....
6.
Bananis E, Murray J, Stockert R, Satir P, Wolkoff A
J Cell Biol
. 2000 Oct;
151(1):179-86.
PMID: 11018063
Endocytic vesicles undergo fission to sort ligand from receptor. Using quantitative immunofluorescence and video imaging, we provide the first in vitro reconstitution of receptor-ligand sorting in early endocytic vesicles derived...
7.
Wolkoff A, Kim R, Pang K
Drug Metab Dispos
. 2000 Jun;
28(7):801-6.
PMID: 10859154
Sinusoidal entry is the first obligatory process preceding intracellular drug removal in liver. Transport of the angiotensin converting enzyme inhibitor enalapril (1-750 microM with [(3)H]enalapril), a substrate of Oatp1, the...
8.
Murray J, Bananis E, Wolkoff A
Mol Biol Cell
. 2000 Feb;
11(2):419-33.
PMID: 10679004
We have previously used the asialoglycoprotein receptor system to elucidate the pathway of hepatocytic processing of ligands such as asialoorosomucoid (ASOR). These studies suggested that endocytic vesicles bind to and...
9.
Glavy J, Wu S, Wang P, Orr G, Wolkoff A
J Biol Chem
. 2000 Jan;
275(2):1479-84.
PMID: 10625701
Recent studies implicate a role in hepatocyte organic anion transport of a plasma membrane protein that has been termed oatp1 (organic anion transport protein 1). Little is known regarding mechanisms...
10.
Stockert R, Spray D, Gao Y, Suadicani S, Ripley C, Novikoff P, et al.
Hepatology
. 1999 Aug;
30(3):740-7.
PMID: 10462381
The Trf1 cell line, selected from the human hepatoma cell line HuH-7, manifests altered trafficking of various plasma membrane proteins. In particular, there is a striking loss of State 2...