A L George Jr
Overview
Explore the profile of A L George Jr including associated specialties, affiliations and a list of published articles.
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Articles
113
Citations
4502
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Recent Articles
1.
Avram M, Stika C, Rasmussen-Torvik L, Ciolino J, Pinheiro E, George Jr A, et al.
Clin Pharmacol Ther
. 2016 Apr;
100(1):31-3.
PMID: 27037844
The physiological changes of pregnancy can affect the pharmacokinetics of a drug, thereby affecting its dose requirements. Because pharmacokinetic (PK) studies in pregnant women have rarely been conducted, evidence-based dosing...
2.
Leckband S, Kelsoe J, Dunnenberger H, George Jr A, Tran E, Berger R, et al.
Clin Pharmacol Ther
. 2013 May;
94(3):324-8.
PMID: 23695185
Human leukocyte antigen B (HLA-B) is a gene that encodes a cell surface protein involved in presenting antigens to the immune system. The variant allele HLA-B*15:02 is associated with an...
3.
Ramirez A, Shaffer C, Delaney J, Sexton D, Levy S, Rieder M, et al.
Pharmacogenomics J
. 2012 May;
13(4):325-9.
PMID: 22584458
Marked prolongation of the QT interval and polymorphic ventricular tachycardia following medication (drug-induced long QT syndrome, diLQTS) is a severe adverse drug reaction (ADR) that phenocopies congenital long QT syndrome...
4.
Pierno S, Camerino G, Cippone V, Rolland J, Desaphy J, De Luca A, et al.
Br J Pharmacol
. 2009 Feb;
156(8):1206-15.
PMID: 19220292
Background And Purpose: Statins and fibrates can produce mild to life-threatening skeletal muscle damage. Resting chloride channel conductance (gCl), carried by the ClC-1 channel, is reduced in muscles of rats...
5.
Wu J, Hendrickson J, Yi Y, George Jr A, Henthorn P, Hitte C, et al.
Anim Genet
. 2004 Sep;
35(5):420-1.
PMID: 15373754
No abstract available.
6.
Abou-Khalil B, Ge Q, Desai R, Ryther R, Bazyk A, Bailey R, et al.
Neurology
. 2002 Jan;
57(12):2265-72.
PMID: 11756608
Background: Generalized epilepsy with febrile seizures plus (GEFS+) is an autosomal dominant syndrome characterized by febrile seizures (FS) and a variety of afebrile generalized seizure types. GEFS+ has previously been...
7.
Desaphy J, De Luca A, Tortorella P, De Vito D, George Jr A, Camerino D
Neurology
. 2001 Nov;
57(10):1849-57.
PMID: 11723275
Background: Myotonia and periodic paralysis caused by sodium channel mutations show variable responses to the anti-myotonic drug mexiletine. Objective: To investigate whether variability among sodium channel mutants results from differences...
8.
Viswanathan P, Bezzina C, George Jr A, Roden D, Wilde A, Balser J
Circulation
. 2001 Sep;
104(10):1200-5.
PMID: 11535580
Background: Mutations in the cardiac sodium (Na) channel gene (SCN5A) give rise to the congenital long-QT syndrome (LQT3) and the Brugada syndrome. Na channel blockade by antiarrhythmic drugs improves the...
9.
George Jr A, Bianchi L, Link E, Vanoye C
Curr Biol
. 2001 Aug;
11(15):R620-8.
PMID: 11516971
Chloride (Cl(-)) is the most abundant extracellular anion in multicellular organisms. Passive movement of Cl(-) through membrane ion channels enables several cellular and physiological processes including transepithelial salt transport, electrical...
10.
Tapper A, George Jr A
J Biol Chem
. 2001 Aug;
276(41):38249-54.
PMID: 11479291
The slowly activating cardiac potassium current (I(Ks)) is generated by a heteromultimeric potassium channel complex consisting of pore-forming (KvLQT1) and accessory (minK) subunits belonging to the KCNQ and KCNE gene...