A L Ager Jr
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Explore the profile of A L Ager Jr including associated specialties, affiliations and a list of published articles.
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15
Citations
134
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Recent Articles
1.
Vennerstrom J, Ager Jr A, Andersen S, Grace J, Wongpanich V, Angerhofer C, et al.
Am J Trop Med Hyg
. 2001 Apr;
62(5):573-8.
PMID: 11289666
The antimalarial peroxide, dispiro-1,2,4,5-tetraoxane WR 148999, was synergistic with chloroquine, quinine, mefloquine, and artemisinin against both D6 and W2 clones of Plasmodium falciparum. In consideration of the contrasting antagonism between...
2.
Vennerstrom J, Dong Y, Andersen S, Ager Jr A, Fu H, Miller R, et al.
J Med Chem
. 2000 Jul;
43(14):2753-8.
PMID: 10893313
Sixteen alkyl-substituted dispiro-1,2,4,5-tetraoxanes (7,8,15, 16-tetraoxadispiro[5.2.5.2]hexadecanes) were synthesized to explore dispiro-1,2,4,5-tetraoxane SAR and to identify tetraoxanes with better oral antimalarial activity than prototype tetraoxane 1 (WR 148999). The tetraoxanes were prepared...
3.
Vennerstrom J, Ager Jr A, Dorn A, Andersen S, Gerena L, Ridley R, et al.
J Med Chem
. 1998 Oct;
41(22):4360-4.
PMID: 9784111
N,N-Bis(7-chloroquinolin-4-yl)heteroalkanediamines 1-11 were synthesized and screened against Plasmodium falciparum in vitro and Plasmodium berghei in vivo. These bisquinolines had IC50 values from 1 to 100 nM against P. falciparum in...
4.
Levander O, Ager Jr A, Beck M
Proc Nutr Soc
. 1995 Jul;
54(2):475-87.
PMID: 8524894
No abstract available.
5.
Levander O, Fontela R, Morris V, Ager Jr A
J Parasitol
. 1995 Feb;
81(1):99-103.
PMID: 7876987
Feeding 20% (w/w) menhaden-fish oil in a standard laboratory chow diet for 4 wk partially protected CBA/CaJ mice from the central nervous system consequences of infection with Plasmodium berghei (ANKA)....
6.
Lin A, Ager Jr A, Klayman D
Am J Trop Med Hyg
. 1994 Jun;
50(6):777-83.
PMID: 8024074
In addition to artelinic acid, which was demonstrated previously to possess good prophylactic as well as curative antimalarial activity against Plasmodium berghei by transdermal administration, seven artemisinin derivatives in a...
7.
Posner G, Oh C, Webster H, Ager Jr A, ROSSAN R
Am J Trop Med Hyg
. 1994 Apr;
50(4):522-6.
PMID: 8166360
We have concluded initial preclinical studies with synthetic trioxanes numbered 3-9 and have compared them with artemisinin (numbered 1) using CD-1 mice infected with Plasmodium berghei. Based on their antimalarial...
8.
Shmuklarsky M, Klayman D, Milhous W, Kyle D, ROSSAN R, Ager Jr A, et al.
Am J Trop Med Hyg
. 1993 Mar;
48(3):377-84.
PMID: 8470775
The antimalarial activity of beta-artemether and beta-arteether was compared in three test systems: in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites, in mice infected with P. berghei, and in...
9.
Levander O, Ager Jr A
Parasitology
. 1993 Jan;
107 Suppl:S95-106.
PMID: 8115190
Susceptibility to oxidative stress is a well-established feature of the malarial parasite. Pharmacologists have taken advantage of this property to design highly effective pro-oxidant antimalarial drugs. Less well appreciated is...
10.
Vennerstrom J, Fu H, Ellis W, Ager Jr A, Wood J, Andersen S, et al.
J Med Chem
. 1992 Aug;
35(16):3023-7.
PMID: 1501229
Dispiro-1,2,4,5-tetraoxanes 2-4 were synthesized as potential peroxide antimalarial drugs. They had curative activity against Plasmodium berghei in vivo at single doses of 320 and 640 mg/kg which confirms earlier unpublished...