J L Vennerstrom
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Explore the profile of J L Vennerstrom including associated specialties, affiliations and a list of published articles.
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33
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431
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Recent Articles
1.
Sanford A, Schulze T, Potluri L, Watson G, Darner E, Zach S, et al.
Int J Parasitol Drugs Drug Resist
. 2018 Dec;
8(3):488-492.
PMID: 30500526
Toxoplasma gondii is an obligate intracellular parasite with global incidence. The acute infection, toxoplasmosis, is treatable but current regimens have poor host tolerance and no cure has been found for...
2.
Sanford A, Schulze T, Potluri L, Hemsley R, Larson J, Judge A, et al.
Parasitol Int
. 2017 Oct;
67(2):107-111.
PMID: 29081387
We profiled three novel T. gondii inhibitors identified from an antimalarial phenotypic high throughput screen (HTS) campaign: styryl 4-oxo-1,3-benzoxazin-4-one KG3, tetrahydrobenzo[b]pyran KG7, and benzoquinone hydrazone KG8. These compounds inhibit T....
3.
Dorn A, Scovill J, Ellis W, Matile H, Ridley R, Vennerstrom J
Am J Trop Med Hyg
. 2001 Aug;
65(1):19-20.
PMID: 11504401
Floxacrine was a promising antimalarial compound that led to the identification of WR 243251. On the basis of their structures, we suspected that these compounds might be good inhibitors of...
4.
Bhattacharjee A, Kyle D, Vennerstrom J
Antimicrob Agents Chemother
. 2001 Aug;
45(9):2655-7.
PMID: 11502547
For imipramine, desipramine, and eight analogs of these well-known drugs, an N-5-aminoalkyl substitution was a minimum but insufficient structural feature associated with chloroquine resistance reversal. Although a second distal aliphatic...
5.
Vennerstrom J, Ager Jr A, Andersen S, Grace J, Wongpanich V, Angerhofer C, et al.
Am J Trop Med Hyg
. 2001 Apr;
62(5):573-8.
PMID: 11289666
The antimalarial peroxide, dispiro-1,2,4,5-tetraoxane WR 148999, was synergistic with chloroquine, quinine, mefloquine, and artemisinin against both D6 and W2 clones of Plasmodium falciparum. In consideration of the contrasting antagonism between...
6.
Ihnat P, Vennerstrom J, Robinson D
J Pharm Sci
. 2000 Oct;
89(12):1525-36.
PMID: 11042600
The poor membrane permeability and oral bioavailability of the iron chelating agent deferoxamine (DFO) mesylate result from the low octanol/water partition coefficient and high aqueous solubility. With the ultimate aim...
7.
Vennerstrom J, Dong Y, Andersen S, Ager Jr A, Fu H, Miller R, et al.
J Med Chem
. 2000 Jul;
43(14):2753-8.
PMID: 10893313
Sixteen alkyl-substituted dispiro-1,2,4,5-tetraoxanes (7,8,15, 16-tetraoxadispiro[5.2.5.2]hexadecanes) were synthesized to explore dispiro-1,2,4,5-tetraoxane SAR and to identify tetraoxanes with better oral antimalarial activity than prototype tetraoxane 1 (WR 148999). The tetraoxanes were prepared...
8.
Vippagunta S, Dorn A, Ridley R, Vennerstrom J
Biochim Biophys Acta
. 2000 Jun;
1475(2):133-40.
PMID: 10832027
Numerous studies indicate that a key feature of chloroquine's (CQ) antimalarial activity is its interaction with hematin. We now characterize this CQ-hematin interaction in detail using isothermal titration calorimetry (ITC)....
9.
McCullough K, Wood J, Bhattacharjee A, Dong Y, Kyle D, Milhous W, et al.
J Med Chem
. 2000 Mar;
43(6):1246-9.
PMID: 10737758
Two tetramethyl-substituted dispiro-1,2,4,5-tetraoxanes (7,8,15, 16-tetraoxadispiro[5.2.5.2]hexadecanes) 3 and 4 were designed as metabolically stable analogues of the dimethyl-substituted dispiro-1, 2,4,5-tetraoxane prototype WR 148999 (2). For a positive control we selected the...
10.
Vippagunta S, Dorn A, Matile H, Bhattacharjee A, Karle J, Ellis W, et al.
J Med Chem
. 1999 Dec;
42(22):4630-9.
PMID: 10579825
Considerable data now support the hypothesis that chloroquine (CQ)-hematin binding in the parasite food vacuole leads to inhibition of hematin polymerization and parasite death by hematin poisoning. To better understand...