A J Shatkin
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Explore the profile of A J Shatkin including associated specialties, affiliations and a list of published articles.
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184
Citations
6098
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Recent Articles
1.
Wen Y, Shatkin A
Genes Dev
. 2000 Dec;
14(23):2944-9.
PMID: 11114884
We screened a human cDNA library for proteins that bind mRNA cap methyltransferase (MT) and isolated nuclear transporter importin-alpha (Impalpha). This direct association was confirmed by glutathione S-transferase (GST) pulldown,...
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3.
Shatkin A, Manley J
Nat Struct Biol
. 2000 Oct;
7(10):838-42.
PMID: 11017188
Nearly all mRNAs are post-transcriptionally modified at their 5' and 3' ends, by capping and polyadenylation, respectively. These essential modifications are of course chemically quite distinct, as are the enzymatic...
4.
Wen Y, Shatkin A
Genes Dev
. 1999 Jul;
13(14):1774-9.
PMID: 10421630
RNA polymerase II nascent transcripts are capped during pausing before elongation. Here we report that hSPT5, the human homolog of yeast elongation factor SPT5, interacts directly with the capping enzyme....
5.
Pillutla R, Shimamoto A, Furuichi Y, Shatkin A
Genomics
. 1999 Mar;
56(2):217-20.
PMID: 10051408
Human p21/SIIR is a novel Ser/Arg/Pro-rich nuclear phosphoprotein that is 48% similar to transcription factor SII and modulates transcription in a promoter context-dependent fashion. We have obtained the complete sequence...
6.
Pillutla R, Shimamoto A, Furuichi Y, Shatkin A
Genomics
. 1998 Nov;
54(2):351-3.
PMID: 9828141
No abstract available.
7.
Wen Y, Yue Z, Shatkin A
Proc Natl Acad Sci U S A
. 1998 Oct;
95(21):12226-31.
PMID: 9770468
Mammalian capping enzymes are bifunctional proteins with both RNA 5'-triphosphatase and guanylyltransferase activities. The N-terminal 237-aa triphosphatase domain contains (I/V)HCXXGXXR(S/T)G, a sequence corresponding to the conserved active-site motif in protein...
8.
Pillutla R, Yue Z, Maldonado E, Shatkin A
J Biol Chem
. 1998 Aug;
273(34):21443-6.
PMID: 9705270
Guanine N-7 methylation is an essential step in the formation of the m7GpppN cap structure that is characteristic of eukaryotic mRNA 5' ends. The terminal 7-methylguanosine is recognized by cap-binding...
9.
Yue Z, Shatkin A
Curr Top Microbiol Immunol
. 1998 May;
233(Pt 1):31-56.
PMID: 9599920
No abstract available.
10.
Yue Z, Maldonado E, Pillutla R, Cho H, Reinberg D, Shatkin A
Proc Natl Acad Sci U S A
. 1997 Dec;
94(24):12898-903.
PMID: 9371772
5'-Capping is an early mRNA modification that has important consequences for downstream events in gene expression. We have isolated mammalian cDNAs encoding capping enzyme. They contain the sequence motifs characteristic...