G W Both
Overview
Explore the profile of G W Both including associated specialties, affiliations and a list of published articles.
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Articles
84
Citations
1700
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Recent Articles
1.
Wang X, Martiniello-Wilks R, Shaw J, Ho T, Coulston N, Cooke-Yarborough C, et al.
Gene Ther
. 2004 Sep;
11(21):1559-67.
PMID: 15343359
Gene-directed enzyme prodrug therapy (GDEPT) based on the Escherichia coli enzyme, purine nucleoside phosphorylase (PNP), provides a novel strategy for treating slowly growing tumors like prostate cancer (CaP). PNP converts...
2.
Voeks D, Martiniello-Wilks R, Madden V, Smith K, Bennetts E, Both G, et al.
Gene Ther
. 2002 Jun;
9(12):759-68.
PMID: 12040457
A gene-directed enzyme pro-drug therapy (GDEPT) based on purine nucleoside phosphorylase (PNP), that converts the prodrug, fludarabine to 2-fluoroadenine, has been described, but studies are limited compared with other GDEPTs....
3.
Voeks D, Both G, CAMERON F, Cooke B, Russell P
Biotechniques
. 2001 Jul;
31(1):46-9.
PMID: 11464519
No abstract available.
4.
Messina M, Yu D, Learoyd D, Both G, Molloy P, Robinson B
Mol Cell Endocrinol
. 2000 Oct;
164(1-2):219-24.
PMID: 11026573
The efficient and high level expression of therapeutic genes in target cells is critical for effective gene therapy. We have developed a novel promoter by utilizing tandem repeats of a...
5.
Loser P, Hillgenberg M, Arnold W, Both G, Hofmann C
Gene Ther
. 2000 Sep;
7(17):1491-8.
PMID: 11001369
Ovine adenovirus (OAV) vectors represent a promising tool for human gene therapy since these vectors overcome the problem of pre-existing immunity against human adenovirus vectors. In this report we investigated...
6.
Xu Z, Nevels M, MacAvoy E, Lockett L, Curiel D, Dobner T, et al.
Virology
. 2000 Apr;
270(1):162-72.
PMID: 10772988
Adenoviruses of the Mastadenovirus and Aviadenovirus genera are able to transform certain cell types and induce tumor formation in susceptible animals. For the mastadenoviruses the E1A/B sequences are largely responsible...
7.
Hofmann C, Loser P, Cichon G, Arnold W, Both G, Strauss M
J Virol
. 1999 Jul;
73(8):6930-6.
PMID: 10400791
Recombinant human adenoviruses (hAd) have become widely used as tools to achieve efficient gene transfer. However, successful application of hAd-derived vectors in clinical trials is limited due to immunological and...
8.
Lockett L, Molloy P, Russell P, Both G
Clin Cancer Res
. 1998 Nov;
3(11):2075-80.
PMID: 9815599
Enzyme-prodrug therapy for the treatment of cancer is an experimental procedure that is under intensive investigation. However, the relative merits of the various systems for use under specific conditions are...
9.
Xu Z, Both G
Virology
. 1998 Aug;
248(1):156-63.
PMID: 9705265
Ovine adenovirus OAV287 (OAV) is phylogenetically and serotypically distinct from human Ad5. OAV grows productively in CSL503 foetal ovine lung cells and abortively infects several human cell lines. OAV has...
10.
Martiniello-Wilks R, Daja M, Russell P, Both G, Molloy P, Lockett L, et al.
Hum Gene Ther
. 1998 Aug;
9(11):1617-26.
PMID: 9694160
Advanced prostate cancer is invariably lethal once it becomes androgen independent (AI). With the aim of developing a new treatment we have used the human androgen-independent prostate cancer cell line,...