A H Sharpe
Overview
Explore the profile of A H Sharpe including associated specialties, affiliations and a list of published articles.
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106
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8134
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Recent Articles
31.
Ling V, Wu P, Finnerty H, Sharpe A, GRAY G, Collins M
Genomics
. 1999 Sep;
60(3):341-55.
PMID: 10493833
CTLA4 (CD152), a receptor for the B7 costimulatory molecules (CD80 and CD86), is considered a fundamental regulator of T-cell activation. In this paper, we present the complete primary structure of...
32.
Mandelbrot D, Furukawa Y, McAdam A, Alexander S, Libby P, Mitchell R, et al.
J Immunol
. 1999 Sep;
163(7):3753-7.
PMID: 10490971
Blockade of the CD28/CTLA4/B7 costimulatory pathway using CTLA4-Ig has great therapeutic potential, and has been shown to prolong allograft survival in a variety of animal models. To gain further insight...
33.
Chang T, Jabs C, Sobel R, Kuchroo V, Sharpe A
J Exp Med
. 1999 Sep;
190(5):733-40.
PMID: 10477557
The importance of B7 costimulation in regulating T cell expansion and peripheral tolerance suggests that it may also play a significant regulatory role in the development of autoimmune disease. It...
34.
Humphries D, Wong G, Friend D, Gurish M, Qiu W, Huang C, et al.
Nature
. 1999 Aug;
400(6746):769-72.
PMID: 10466726
All mammals produce heparin, a negatively charged glycosaminoglycan that is a major constituent of the secretory granules of mast cells which are found in the peritoneal cavity and most connective...
35.
Oosterwegel M, Mandelbrot D, Boyd S, Lorsbach R, Jarrett D, Abbas A, et al.
J Immunol
. 1999 Aug;
163(5):2634-9.
PMID: 10453003
To examine the role of CTLA-4 in Th cell differentiation, we used two newly generated CTLA-4-deficient (CTLA-4-/-) mouse strains: DO11. 10 CTLA-4-/- mice carrying a class II restricted transgenic TCR...
36.
Liang B, Gee R, Kashgarian M, Sharpe A, Mamula M
J Immunol
. 1999 Aug;
163(4):2322-9.
PMID: 10438978
Costimulatory molecules, termed B7.1 and B7.2, are present on the surfaces of APC and are important for the activation of T lymphocytes specific for both foreign Ags and autoantigens. We...
37.
Lynch W, Sharpe A, Snyder E
J Virol
. 1999 Jul;
73(8):6841-51.
PMID: 10400782
The induction of spongiform myeloencephalopathy by murine leukemia viruses is mediated primarily by infection of central nervous system (CNS) microglia. In this regard, we have previously shown that CasBrE-induced disease...
38.
Oosterwegel M, Greenwald R, Mandelbrot D, Lorsbach R, Sharpe A
Curr Opin Immunol
. 1999 Jun;
11(3):294-300.
PMID: 10375557
The past year has seen significant advances in our understanding of the role of cytotoxic T lymphocyte antigen 4 (CTLA-4) in regulating T cell activation and tolerance. Recent studies indicate...
39.
Blazar B, Taylor P, Panoskaltsis-Mortari A, Sharpe A, Vallera D
J Immunol
. 1999 Jun;
162(11):6368-77.
PMID: 10352249
Blockade with B7 antagonists interferes with CD28:B7 and CTLA-4:B7 interactions, which may have opposing effects. We have examined the roles of CD28:B7 and CTLA-4:B7 on in vivo alloresponses. A critical...
40.
Khattri R, Auger J, Griffin M, Sharpe A, Bluestone J
J Immunol
. 1999 May;
162(10):5784-91.
PMID: 10229811
Mice lacking CTLA-4 die at an age of 2-3 wk due to massive lymphoproliferation, leading to lymphocytic infiltration and destruction of major organs. The onset of the lymphoproliferative disease can...