A H Sharpe
Overview
Explore the profile of A H Sharpe including associated specialties, affiliations and a list of published articles.
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106
Citations
8134
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Recent Articles
21.
Kinoshita K, TESCH G, Schwarting A, Maron R, Sharpe A, Kelley V
J Immunol
. 2000 May;
164(11):6046-56.
PMID: 10820290
Autoimmune lupus nephritis is dependent on infiltrating autoreactive leukocytes and Igs. B7 costimulatory molecules (B7-1 and B7-2) provide signals essential for T cell activation and Ig class switching. In MRL-Faslpr...
22.
Yu X, Fournier S, Allison J, Sharpe A, Hodes R
J Immunol
. 2000 Mar;
164(7):3543-53.
PMID: 10725709
The effect of B7-mediated costimulation on T cell homeostasis was examined in studies of B7-1 (CD80) and B7-2 (CD86) transgenic as well as B7-deficient mice. B7 overexpression in transgenic mice...
23.
Qian J, Collins M, Sharpe A, HOYER L
Blood
. 2000 Feb;
95(4):1324-9.
PMID: 10666206
Inhibitory antibody formation is a major complication of factor VIII replacement therapy in patients with hemophilia A. To better understand the pathogenesis of this immunologic reaction, we evaluated the role...
24.
Anderson D, Sharpe A, Hafler D
Curr Opin Immunol
. 2000 Jan;
11(6):677-83.
PMID: 10631554
The past year has seen significant advances in our understanding of the role of the B7-CD28/CTLA-4 pathway in regulating the responses of self-reactive T cells, giving impetus to manipulation of...
25.
Lynch W, Sharpe A
J Virol
. 2000 Jan;
74(3):1558-65.
PMID: 10627570
The wild mouse ecotropic retrovirus, Cas-Br-E, induces progressive, noninflammatory spongiform neurodegenerative disease in susceptible mice. Functional genetic analysis of the Cas-Br-E genome indicates that neurovirulence maps to the env gene,...
26.
Chen A, McAdam A, Buhlmann J, Scott S, Lupher Jr M, Greenfield E, et al.
Immunity
. 2000 Jan;
11(6):689-98.
PMID: 10626891
The tumor necrosis factor family molecule Ox40-ligand (Ox40L) has been identified as a potential costimulatory molecule and also has been implicated in T cell homing and B cell activation. To...
27.
McAdam A, Farkash E, Gewurz B, Sharpe A
J Virol
. 1999 Dec;
74(1):203-8.
PMID: 10590107
Antibody and cytotoxic T-lymphocyte (CTL) responses have critical roles in eliminating many viral infections. In addition to stimulation of the T-cell receptor, T cells require costimulatory signals to respond optimally....
28.
29.
Guttormsen H, Sharpe A, Chandraker A, Brigtsen A, Sayegh M, Kasper D
Infect Immun
. 1999 Nov;
67(12):6375-84.
PMID: 10569753
Covalent linkage of a bacterial polysaccharide to an immunogenic protein greatly enhances the carbohydrate's immunogenicity and induces polysaccharide-specific B-cell memory in vivo. These findings have spurred the development of glycoconjugate...
30.
Schweitzer A, Sharpe A
J Immunol
. 1999 Oct;
163(9):4819-25.
PMID: 10528182
We have used T cells from B7-1-deficient TCR transgenic DO11.10 mice to demonstrate a functional role for B7-1 on T cells. B7-1-deficient DO11.10 T cells produce more IL-4 than wild-type...