A H Sharpe
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Explore the profile of A H Sharpe including associated specialties, affiliations and a list of published articles.
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106
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8134
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Recent Articles
11.
Latchman Y, Wood C, Chernova T, Chaudhary D, Borde M, Chernova I, et al.
Nat Immunol
. 2001 Feb;
2(3):261-8.
PMID: 11224527
Programmed death I (PD-I)-deficient mice develop a variety of autoimmune-like diseases, which suggests that this immunoinhibitory receptor plays an important role in tolerance. We identify here PD-1 ligand 2 (PD-L2)...
12.
Szot G, Zhou P, Sharpe A, He G, Kim O, Newell K, et al.
Transplantation
. 2001 Feb;
69(5):904-9.
PMID: 10755548
CD28 antagonists have been shown to promote long-term graft survival and induce donor-specific tolerance. In this study, the role of CD28/B7 costimulation and the relative importance of host versus donor...
13.
Functional equivalency of B7-1 and B7-2 for costimulating plasmid DNA vaccine-elicited CTL responses
Santra S, Barouch D, Jackson S, Kuroda M, Schmitz J, Lifton M, et al.
J Immunol
. 2000 Dec;
165(12):6791-5.
PMID: 11120800
A costimulatory signal in addition to an Ag-specific stimulus is required for optimal activation of T lymphocytes. CD28, the primary positive costimulatory receptor on T cells, has two identified ligands,...
14.
Gaglia J, Greenfield E, Mattoo A, Sharpe A, Freeman G, Kuchroo V
J Immunol
. 2000 Nov;
165(11):6091-8.
PMID: 11086041
Presentation of Ag to T lymphocytes in the absence of the requisite costimulatory signals leads to an Ag-specific unresponsiveness termed anergy, whereas Ag presentation in conjunction with costimulation leads to...
15.
McAdam A, Chang T, Lumelsky A, Greenfield E, Boussiotis V, Duke-Cohan J, et al.
J Immunol
. 2000 Oct;
165(9):5035-40.
PMID: 11046032
The inducible costimulatory (ICOS) molecule is expressed by activated T cells and has homology to CD28 and CD152. ICOS binds B7h, a molecule expressed by APC with homology to CD80...
16.
Santra S, Barouch D, Sharpe A, Letvin N
Eur J Immunol
. 2000 Sep;
30(9):2650-9.
PMID: 11009099
Whether B7-1 and B7-2 have distinct functions for eliciting immune responses to antigens that are presented to the immune system by intracellular and extracellular antigen processing pathways is an unresolved...
17.
Liang B, Kashgarian M, Sharpe A, Mamula M
J Immunol
. 2000 Sep;
165(6):3436-43.
PMID: 10975864
The activation of T lymphocytes requires both Ag-mediated signaling through the TCR as well as costimulatory signals transmitted through B7-1 and/or B7-2 with CD28. The interference of B7-mediated costimulatory signals...
18.
McAdam A, Gewurz B, Farkash E, Sharpe A
J Immunol
. 2000 Sep;
165(6):3088-93.
PMID: 10975820
B7-1 and B7-2 are important costimulatory molecules in the activation of T cell immunity. We have used mice made genetically deficient in either or both B7 molecules to determine the...
19.
Furukawa Y, Mandelbrot D, Libby P, Sharpe A, Mitchell R
Am J Pathol
. 2000 Aug;
157(2):473-84.
PMID: 10934151
To investigate the roles of B7-1 and/or B7-2 co-stimulatory molecule in the development of graft arterial disease (GAD), major histocompatibility complex (MHC) class II-mismatched allograft hearts were transplanted into wild-type,...
20.
Klaman L, Boss O, Peroni O, Kim J, Martino J, Zabolotny J, et al.
Mol Cell Biol
. 2000 Jul;
20(15):5479-89.
PMID: 10891488
Protein-tyrosine phosphatase 1B (PTP-1B) is a major protein-tyrosine phosphatase that has been implicated in the regulation of insulin action, as well as in other signal transduction pathways. To investigate the...