A H Sharpe
Overview
Explore the profile of A H Sharpe including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
106
Citations
8134
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Riella L, Paterson A, Sharpe A, Chandraker A
Am J Transplant
. 2012 Aug;
12(10):2575-87.
PMID: 22900886
Understanding immunoregulatory mechanisms is essential for the development of novel interventions to improve long-term allograft survival. Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, have emerged as critical...
2.
Riella L, Watanabe T, Sage P, Yang J, Yeung M, Azzi J, et al.
Am J Transplant
. 2011 Mar;
11(4):832-40.
PMID: 21401869
The PD1:PDL1 pathway is an essential negative costimulatory pathway that plays a key role in regulating the alloimune response. PDL1 is expressed not only on antigen-presenting cells (APCs) but also...
3.
Akbari O, Stock P, Singh A, Lombardi V, Lee W, Freeman G, et al.
Mucosal Immunol
. 2009 Sep;
3(1):81-91.
PMID: 19741598
Interactions of the inhibitory receptor programmed death-1 (PD-1) with its ligands, programmed death ligand (PD-L)1 and PD-L2, regulate T-cell activation and tolerance. In this study, we investigated the role of...
4.
Mandelbrot D, Kishimoto K, Auchincloss Jr H, Sharpe A, Sayegh M
J Immunol
. 2001 Jul;
167(3):1174-8.
PMID: 11466331
The activation of T cells by B7 costimulation in trans has been demonstrated in vitro, but the in vivo relevance is unknown. To study costimulation in trans of CD4(+) T...
5.
Yamada A, Kishimoto K, Dong V, Sho M, Salama A, Anosova N, et al.
J Immunol
. 2001 Jun;
167(1):140-6.
PMID: 11418642
T cell costimulation by B7 molecules plays an important role in the regulation of alloimmune responses. Although both B7-1 and B7-2 bind CD28 and CTLA-4 on T cells, the role...
6.
Yoshida K, Kuo F, George E, Sharpe A, Dutta A
Mol Cell Biol
. 2001 Jun;
21(14):4598-603.
PMID: 11416137
CDC45 is required for the initiation of DNA replication in Saccharomyces cerevisiae and functions as a DNA polymerase alpha loading factor in Xenopus, but its role in mammalian DNA replication...
7.
McAdam A, Greenwald R, Levin M, Chernova T, Malenkovich N, Ling V, et al.
Nature
. 2001 May;
409(6816):102-5.
PMID: 11343122
The inducible co-stimulatory molecule (ICOS) is a CD28 homologue implicated in regulating T-cell differentiation. Because co-stimulatory signals are critical for regulating T-cell activation, an understanding of co-stimulatory signals may enable...
8.
Wu C, Nguyen K, Pien G, Wang N, Gullo C, Howie D, et al.
Nat Immunol
. 2001 Apr;
2(5):410-4.
PMID: 11323694
SH2D1A, which encodes signaling lymphocyte activation molecule (SLAM)-associated protein (SAP), is altered in patients with X-linked lymphoproliferative disease (XLP), a primary immunodeficiency. SAP-deficient mice infected with lymphocytic choriomeningitis virus had...
9.
Mandelbrot D, Oosterwegel M, Shimizu K, Yamada A, Freeman G, Mitchell R, et al.
J Clin Invest
. 2001 Apr;
107(7):881-7.
PMID: 11285307
To examine whether B7 costimulation can be mediated by a molecule on T cells that is neither CD28 nor CTLA4, we generated mice lacking both of these receptors. CD28/CTLA4(-/-) mice...
10.
Greenwald R, Boussiotis V, Lorsbach R, Abbas A, Sharpe A
Immunity
. 2001 Mar;
14(2):145-55.
PMID: 11239447
The requirement for CTLA-4 during the induction of peripheral T cell tolerance in vivo was investigated using naive TCR transgenic T cells lacking CTLA-4. CTLA-4(-/-) T cells are resistant to...