A C Gingras
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Explore the profile of A C Gingras including associated specialties, affiliations and a list of published articles.
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44
Citations
6228
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Recent Articles
1.
Gingras A, Raught B, Sonenberg N
Curr Top Microbiol Immunol
. 2003 Oct;
279:169-97.
PMID: 14560958
Over the past few years, the target of rapamycin (TOR) pathway has been implicated in the control of translation, both in yeast and in higher eukaryotes. In this review, we...
2.
Gingras A, Raught B, Gygi S, Niedzwiecka A, Miron M, Burley S, et al.
Genes Dev
. 2001 Nov;
15(21):2852-64.
PMID: 11691836
In most instances, translation is regulated at the initiation phase, when a ribosome is recruited to the 5' end of an mRNA. The eIF4E-binding proteins (4E-BPs) interdict translation initiation by...
3.
Tsukiyama-Kohara K, Poulin F, Kohara M, DeMaria C, Cheng A, Wu Z, et al.
Nat Med
. 2001 Oct;
7(10):1128-32.
PMID: 11590436
All nuclear-encoded mRNAs contain a 5' cap structure (m7GpppN, where N is any nucleotide), which is recognized by the eukaryotic translation initiation factor 4E (eIF4E) subunit of the eIF4F complex....
4.
Gingras A, Raught B, Sonenberg N
Prog Mol Subcell Biol
. 2001 Sep;
27:143-74.
PMID: 11575159
No abstract available.
5.
Raught B, Gingras A, Sonenberg N
Proc Natl Acad Sci U S A
. 2001 Jun;
98(13):7037-44.
PMID: 11416184
Rapamycin potently inhibits downstream signaling from the target of rapamycin (TOR) proteins. These evolutionarily conserved protein kinases coordinate the balance between protein synthesis and protein degradation in response to nutrient...
6.
Gingras A, Raught B, Sonenberg N
Genes Dev
. 2001 Apr;
15(7):807-26.
PMID: 11297505
No abstract available.
7.
Bhandari B, Feliers D, Duraisamy S, Stewart J, Gingras A, Abboud H, et al.
Kidney Int
. 2001 Mar;
59(3):866-75.
PMID: 11231341
Background: Augmented protein translation by insulin involves activation of eukaryotic initiation factor 4E (eIF4E) that follows release of eIF4E from a heterodimeric complex by phosphorylation of its inhibitory binding protein,...
8.
Kumar V, Sabatini D, Pandey P, Gingras A, Majumder P, Kumar M, et al.
J Biol Chem
. 2001 Feb;
275(15):10779-87.
PMID: 10753870
The c-Abl protein-tyrosine kinase is activated by ionizing radiation and certain other DNA-damaging agents. The rapamycin and FKBP-target 1 (RAFT1), also known as FKBP12-rapamycin-associated protein (FRAP, mTOR), regulates the p70S6...
9.
Gingras A, Raught B, Sonenberg N
Annu Rev Biochem
. 2000 Jun;
68:913-63.
PMID: 10872469
Eukaryotic translation initiation factor 4F (eIF4F) is a protein complex that mediates recruitment of ribosomes to mRNA. This event is the rate-limiting step for translation under most circumstances and a...
10.
Polunovsky V, Gingras A, Sonenberg N, Peterson M, Tan A, Rubins J, et al.
J Biol Chem
. 2000 May;
275(32):24776-80.
PMID: 10811643
Activated Ras has been shown to provide powerful antiapoptotic signals to cells through well defined transcriptional and post- translational pathways, whereas translational control as a mechanism of Ras survival signaling...