A B Jefferson
Overview
Explore the profile of A B Jefferson including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
20
Citations
976
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Lin X, Murray J, Rico A, Wang M, Chu D, Zhou Y, et al.
Bioorg Med Chem Lett
. 2006 Jun;
16(16):4163-8.
PMID: 16765046
A series of 2-pyrimidyl-5-amidothiophenes has been synthesized and evaluated for AKT inhibition. SAR studies resulted in potent inhibitors of AKT with IC(50) values as low as single digit nanomolar as...
2.
Yan D, Wiesmann M, Rohan M, Chan V, Jefferson A, Guo L, et al.
Proc Natl Acad Sci U S A
. 2001 Dec;
98(26):14973-8.
PMID: 11752446
Genetic studies have identified mutations in key regulators of the Wnt/beta-catenin pathway in a variety of cancers, most frequently in colon cancers. However, whether the pathway is activated in clinical...
3.
Zundel W, Schindler C, Koong A, Kaper F, Chen E, Gottschalk A, et al.
Genes Dev
. 2000 Feb;
14(4):391-6.
PMID: 10691731
In glioblastoma-derived cell lines, PTEN does not significantly alter apoptotic sensitivity or cause complete inhibition of DNA synthesis. However, in these cell lines PTEN regulates hypoxia- and IGF-1-induced angiogenic gene...
4.
Jefferson A, Klippel A, Williams L
Oncogene
. 1998 Jun;
16(18):2303-10.
PMID: 9620547
There are several recently reported examples of inositol phospholipids binding to pleckstrin homology (PH) domains of proteins. The PH domain of SOS, a guanine nucleotide exchange factor for Ras, binds...
5.
The role of erythropoietin receptor tyrosine phosphorylation in erythropoietin-induced proliferation
Damen J, Liu L, Wakao H, Miyajima A, Rosten P, Jefferson A, et al.
Leukemia
. 1997 Apr;
11 Suppl 3:423-5.
PMID: 9209412
Although studies with truncated erythropoietin receptors (EpoRs) have suggested the tyrosine phosphorylation (Yphos) of the EpoR may not play a significant role in Epo-induced proliferation, we found, using a full...
6.
Jefferson A, Auethavekiat V, Pot D, Williams L, MAJERUS P
J Biol Chem
. 1997 Feb;
272(9):5983-8.
PMID: 9038219
An inositol polyphosphate-5-phosphatase (SIP-110) that binds the SH3 domains of the adaptor protein GRB2 was produced in Sf9 cells and characterized. SIP-110 binds to GRB2 in vitro with a stoichiometry...
7.
Liu L, Jefferson A, Zhang X, Norris F, MAJERUS P, Krystal G
J Biol Chem
. 1996 Nov;
271(47):29729-33.
PMID: 8939907
To gain insight into the intracellular signaling cascades that are activated by the binding of interleukin-3 (IL-3) to its target cells, we have embarked on the identification of proteins that...
8.
Jefferson A, MAJERUS P
Biochemistry
. 1996 Jun;
35(24):7890-4.
PMID: 8672490
Two short amino acid motifs, WXGDXNXR and PXWCDRXL, define a large family of inositol polyphosphate 5-phosphatases. We tested the importance of seven of these conserved amino acids to substrate binding...
9.
Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2
Kavanaugh W, Pot D, Chin S, Jefferson A, Norris F, Masiarz F, et al.
Curr Biol
. 1996 Apr;
6(4):438-45.
PMID: 8723348
Background: Shc and Grb2 form a complex in cells in response to growth factor stimulation and link tyrosine kinases to Ras during the resulting signaling process. Shc and Grb2 each...
10.
Damen J, Liu L, Rosten P, Humphries R, Jefferson A, MAJERUS P, et al.
Proc Natl Acad Sci U S A
. 1996 Feb;
93(4):1689-93.
PMID: 8643691
A 145-kDa tyrosine-phosphorylated protein that becomes associated with Shc in response to multiple cytokines has been purified from the murine hemopoietic cell line B6SUtA1. Amino acid sequence data were used...