Idiotypic Cross-reactivity Between Antibodies of Different Specificities

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1978 Dec 1

PMID 82603

Citations 17

Authors

R Karol

M Reichlin

R W Noble

Affiliations

Soon will be listed here.

Abstract

Cross-idiotypic specificity has been demonstrated between antibody populations of different specificities using antibodies directed toward human sickle cell hemoglobin (HbS). A site-specific antibody directed toward the beta6-position of HbS, anti-Val, was used to elicit an anti-idiotypic response in rabbits. Using this anti-idiotypic serum, idiotypic cross-reactivity was demonstrated between antibody populations that bind to human adult hemoglobin (HbA). It was demonstrated that in the case of the goat antibodies, these idiotypically cross-reacting antibodies are directed towards the beta6-position of the hemoglobin molecule. However, they differ in their specificity, binding to this site on HbA, whereas anti-Val binds only to HbS. The sheep antibody populations directed toward HbS differ qualitatively from those of the goat. Using rabbit anti-idiotypic serum specific for sheep anti-Val, cross-reactivity could be demonstrated with antibodies directed toward the alpha-chain of the hemoglobin molecule, as well as the beta-chain. There was also a low level of cross-reactivity with antibodies from a goat immunized with HbA.

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References

OUDIN J, Michel M . [A new allotype form of rabbit serum gamma-globulins, apparently associated with antibody function and specificity]. C R Hebd Seances Acad Sci. 1963; 257:805-8. View

DOZY A, HUISMAN T . Studies on the heterogeneity of hemoglobin. XIV. Chromatography of normal and abnormal human hemoglobin types on CM-Sephadex. J Chromatogr. 1969; 40(1):62-70. DOI: 10.1016/s0021-9673(01)96618-x. View

Tung A, Nisonoff A . Isolation from individual A/J mice of anti-rho-azophenylarsonate antibodies bearing a cross-reactive idiotype. J Exp Med. 1975; 141(1):112-26. PMC: 2190504. DOI: 10.1084/jem.141.1.112. View

CLAFLIN J, Davie J . Clonal nature of the immune response to phosphorylcholine (PC). V. Cross-idiotypic specificity among heavy chains of murine anti-PC antibodies and PC-binding myeloma proteins. J Exp Med. 1975; 141(5):1073-83. PMC: 2189783. DOI: 10.1084/jem.141.5.1073. View

Karol R, Reichlin M, Noble R . Evolution of an idiotypic determinant: anti-Val. J Exp Med. 1977; 146(2):435-44. PMC: 2180777. DOI: 10.1084/jem.146.2.435. View

Tan-Wilson A, Reichlin M, Noble R . Properties of goat anti-human hemoglobin antibodies fractionated on subunit affinity columns. Immunochemistry. 1976; 13(6):491-8. DOI: 10.1016/0019-2791(76)90324-4. View

Potter M, Lieberman R . Common individual antigenic determinants in five of eight BALB-c IgA myeloma proteins that bind phosphoryl choline. J Exp Med. 1970; 132(4):737-51. PMC: 2138855. DOI: 10.1084/jem.132.4.737. View

Eichmann K, Kindt T . The inheritance of individual antigenic specificities of rabbit antibodies to streptococcal carbohydrates. J Exp Med. 1971; 134(2):532-52. PMC: 2139045. DOI: 10.1084/jem.134.2.532. View

FRANKLIN E, Frangione B . Common structural and antigenic properties of human gamma M anti-gamma globulins. J Immunol. 1971; 107(6):1527-34. View

10.

OUDIN J, Cazenave P . Similar idiotypic specificities in immunoglobulin fractions with different antibody functions or even without detectable antibody function. Proc Natl Acad Sci U S A. 1971; 68(10):2616-20. PMC: 389480. DOI: 10.1073/pnas.68.10.2616. View

11.

Kuettner M, Wang A, Nisonoff A . Quantitative investigations of idiotypic antibodies. VI. Idiotypic specificity as a potential genetic marker for the variable regions of mouse immunoglobulin polypeptide chains. J Exp Med. 1972; 135(3):579-95. PMC: 2139137. DOI: 10.1084/jem.135.3.579. View

12.

Noble R, Reichlin M, Schreiber R . Studies on antibodies directed toward single antigenic sites on globular proteins. Biochemistry. 1972; 11(18):3326-32. DOI: 10.1021/bi00768a004. View

13.

Sher A, Cohn M . Inheritance of an idiotype associated with the immune response of inbred mice to phosphorylcholine. Eur J Immunol. 1972; 2(4):319-26. DOI: 10.1002/eji.1830020405. View

14.

Carson D, Weigert M . Immunochemical analysis of the cross-reacting idiotypes of mouse myeloma proteins with anti-dextran activity and normal anti-dextran antibody. Proc Natl Acad Sci U S A. 1973; 70(1):235-9. PMC: 433222. DOI: 10.1073/pnas.70.1.235. View

15.

KUNKEL H, Agnello V, Joslin F, Winchester R, Capra J . Cross-idiotypic specificity among monoclonal IgM proteins with anti- -globulin activity. J Exp Med. 1973; 137(2):331-42. PMC: 2139491. DOI: 10.1084/jem.137.2.331. View

16.

KELUS A, Gell P . Immunological analysis of rabbit anti-antibody systems. J Exp Med. 1968; 127(1):215-34. PMC: 2138426. DOI: 10.1084/jem.127.1.215. View

17.

Willims Jr R, KUNKEL H, Capra J . Antigenic specificities related to the cold agglutinin activity of gamma M globulins. Science. 1968; 161(3839):379-81. DOI: 10.1126/science.161.3839.379. View

18.

Schreiber R, Reichlin M . The occurrence of shared idiotypic specificity among the goat antibodies that distinguish human hemoglobin S from A. J Immunol. 1974; 113(1):359-66. View

19.

OUDIN J, Michel M . Idiotypy of rabbit antibodies. I. Comparison of idiotypy of antibodies against Salmonella typhi with that of antibodies against other bacteria in the same rabbits, or of antibodies against Salmonella typhi in various rabbits. J Exp Med. 1969; 130(3):595-617. PMC: 2138715. DOI: 10.1084/jem.130.3.595. View

20.

Briles D, Krause R . Mouse strain-specific idiotypy and interstrain idiotypic cross-reactions. J Immunol. 1974; 113(2):522-30. View