Shared Idiotypes Among Monoclonal Antibodies Specific for Different Immunodominant Sugars of Lipopolysaccharide of Different Gram-negative Bacteria

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1982 Mar 1

PMID 6175969

Citations 13

Authors

J Hiernaux

C A Bona

Affiliations

Soon will be listed here.

Abstract

Shared idiotypes (Ids) were identified on monoclonal antibodies specific for different immunodominant sugars in the lipopolysaccharide (LPS) of Gram-negative bacteria. The first group of monoclonal antibodies is specific for Escherichia coli 0113 LPS, whereas the second group is specific for Salmonella tranaroa LPS. The shared idiotopes borne by these two groups of monoclonal antibodies were identified with monoclonal anti-Id antibodies specific for E. coli LPS-binding monoclonal antibodies and with syngeneic anti-384Id antibodies specific for MOPC 384 and MOPC 870 myeloma proteins. Our data suggest that shared idiotopes are common for antibodies for an antigenic family.

Citing Articles

Idiotype-antiidiotype regulation. V. The requirement for immunization with antigen or monoclonal antiidiotypic antibodies for the activation of beta 2 leads to 6 and beta 2 leads to 1 polyfructosan-reactive clones in BALB/c mice treated at birth....

Rubinstein L, Goldberg B, Hiernaux J, STEIN K, Bona C J Exp Med. 1983; 158(4):1129-44.

PMID: 6604783 PMC: 2187361. DOI: 10.1084/jem.158.4.1129.

Shared idiotopes among monoclonal antibodies specific for A/PR/8/34 (H1N1) and X-31(H3N2) influenza viruses.

Moran T, Liu Y, SCHULMAN J, Bona C Proc Natl Acad Sci U S A. 1984; 81(6):1809-12.

PMID: 6584913 PMC: 345010. DOI: 10.1073/pnas.81.6.1809.

Polymorphism of heavy chain immunoglobulin isotypes in the Mus subgenus. I. Limited gamma 3 polymorphism revealed by antibodies raised in SPE wild-derived inbred strain.

Amor M, Bonhomme F, Guenet J, PETTER F, Cazenave P Immunogenetics. 1984; 20(5):577-81.

PMID: 6437976 DOI: 10.1007/BF00364359.

Internal images of antigens within the immune network.

Augustin A, Sim G, Bona C Surv Immunol Res. 1983; 2(1):78-87.

PMID: 6359324 DOI: 10.1007/BF02918398.

Idiotype-antiidiotype regulation. IV. Expression of common regulatory idiotopes on fructosan-binding and non-fructosan-binding monoclonal immunoglobulin.

Goldberg B, Paul W, Bona C J Exp Med. 1983; 158(2):515-28.

PMID: 6193225 PMC: 2187338. DOI: 10.1084/jem.158.2.515.

References

OUDIN J, Cazenave P . Similar idiotypic specificities in immunoglobulin fractions with different antibody functions or even without detectable antibody function. Proc Natl Acad Sci U S A. 1971; 68(10):2616-20. PMC: 389480. DOI: 10.1073/pnas.68.10.2616. View

Cazenave P . [Idiotypy of antibodies against human serum albumin in immunized rabbit serum, which are directed against different regions of this antigen]. FEBS Lett. 1973; 31(3):348-54. DOI: 10.1016/0014-5793(73)80139-5. View

Clevinger B, Schilling J, Hood L, Davie J . Structural correlates of cross-reactive and individual idiotypic determinants on murine antibodies to alpha-(1 leads to 3) dextran. J Exp Med. 1980; 151(5):1059-70. PMC: 2185843. DOI: 10.1084/jem.151.5.1059. View

Sakato N, Fujio H, Amano T . Idiotypic analysis of antibodies to hen egg-white lysozyme (HEL). I. Occurrence of species-specific cross-reactive idiotypes of antibodies directed to distinct regions of HEL in guinea pigs. J Immunol. 1980; 124(4):1866-74. View

OUDIN J, Michel M . [A new allotype form of rabbit serum gamma-globulins, apparently associated with antibody function and specificity]. C R Hebd Seances Acad Sci. 1963; 257:805-8. View

KUNKEL H, Mannik M, Williams R . Individual Antigenic Specificity of Isolated Antibodies. Science. 1963; 140(3572):1218-9. DOI: 10.1126/science.140.3572.1218. View

Eichmann K, Coutinho A, Melchers F . Absolute frequencies of lipopolysaccharide-reactive B cells producing A5A idiotype in unprimed, streptococcal A carbohydrate-primed, anti-A5A idiotype-sensitized and anti-A5A idiotype-suppressed A/J mice. J Exp Med. 1977; 146(5):1436-49. PMC: 2180974. DOI: 10.1084/jem.146.5.1436. View

Karol R, Reichlin M, Noble R . Idiotypic cross-reactivity between antibodies of different specificities. J Exp Med. 1978; 148(6):1488-97. PMC: 2185111. DOI: 10.1084/jem.148.6.1488. View

Liu Y, Bona C, SCHULMAN J . Idiotypy of clonal responses to influenza virus hemagglutinin. J Exp Med. 1981; 154(5):1525-38. PMC: 2186501. DOI: 10.1084/jem.154.5.1525. View

10.

Ju S, Benacerraf B, Dorf M . Genetic control of a shared idiotype among antibodies directed to distinct specificities. J Exp Med. 1980; 152(1):170-82. PMC: 2185899. DOI: 10.1084/jem.152.1.170. View

11.

Wells J, Fudenberg H, Givol D . Localization of idiotypic antigenic determinants in the Fv region of murine myeloma protein MOPC-315. Proc Natl Acad Sci U S A. 1973; 70(5):1585-7. PMC: 433547. DOI: 10.1073/pnas.70.5.1585. View

12.

Potter M . Antigen-binding myeloma proteins of mice. Adv Immunol. 1977; 25:141-211. View

13.

Bona C, Mongini P, STEIN K, Paul W . Anti-immunoglobulin antibodies. I. Expression of cross-reactive idiotypes and Ir gene control of the response to IgG2a of the b allotype. J Exp Med. 1980; 151(6):1334-48. PMC: 2185882. DOI: 10.1084/jem.151.6.1334. View

14.

KABAT E . Origins of antibody complementarity and specificity--hypervariable regions and minigene hypothesis. J Immunol. 1980; 125(3):961-9. View

15.

Bona C, Paul W . Cellular basis of regulation of expression of idiotype. I. T-suppressor cells specific for MOPC 460 idiotype regulate the expression of cells secreting anti-TNP antibodies bearing 460 idiotype. J Exp Med. 1979; 149(3):592-600. PMC: 2184836. DOI: 10.1084/jem.149.3.592. View

16.

Bona C, Heber-Katz E, Paul W . Idiotype-anti-idiotype regulation. I. Immunization with a levan-binding myeloma protein leads to the appearance of auto-anti-(anti-idiotype) antibodies and to the activation of silent clones. J Exp Med. 1981; 153(4):951-67. PMC: 2186140. DOI: 10.1084/jem.153.4.951. View

17.

Bona C, Mond J, STEIN K, House S, Lieberman R, Paul W . Immune response to levan. III. The capacity to produce anti-inulin antibodies and cross-reactive idiotypes appears late in ontogeny. J Immunol. 1979; 123(4):1484-90. View

18.

Landy M, Sanderson R, Jackson A . Humoral and cellular aspects of the immune response to the somatic antigen of Salmonella enteritidis. J Exp Med. 1965; 122(3):483-504. PMC: 2138075. DOI: 10.1084/jem.122.3.483. View