The Specific Recognition by Macrophages of CD8+,CD45RO+ T Cells Undergoing Apoptosis: a Mechanism for T Cell Clearance During Resolution of Viral Infections

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1994 Nov 1

PMID 7964470

Citations 21

Authors

A N Akbar

J Savill

W Gombert

M Bofill

N J Borthwick

F Whitelaw

J Grundy

G Janossy

M Salmon

Affiliations

Soon will be listed here.

Abstract

During viral infections, CD8+,CD45RO+ T populations expand. These primed cells express abundant levels of cytoplasmic granules that contain perforin and TIA-1. Recent work has suggested that the majority of this CD8+ population downregulates Bcl-2 protein expression and is destined to undergo apoptosis. In this study we have investigated the elimination of these apoptotic CD8+ T cells by both human monocyte-derived and murine bone marrow macrophages. We have found that these phagocytes recognize and ingest both apoptotic CD8+ and CD4+ T cells using an alpha v beta 3 (vitronectin receptor)/CD36/thrombospondin recognition system, with the same receptors being used in the recognition of apoptotic neutrophils. These data provide new evidence for a mechanism that enables the clearance of greatly increased populations of CD8+ effector cells which are found during viral infections. This enables cellular homeostasis to occur in the host upon resolution of viral diseases in vivo.

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Intracellular calcium signalling patterns reflect the differentiation status of human T cells.

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Monocytes recruited to the lungs of mice during immune inflammation ingest apoptotic cells poorly.

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