Focal Segmental Glomerular Sclerosis, a Type of Intractable Chronic Glomerulonephritis, is a Stem Cell Disorder

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1994 Mar 1

PMID 7906704

Citations 11

Authors

M Nishimura

J Toki

K Sugiura

F Hashimoto

T Tomita

H Fujishima

Y Hiramatsu

N Nishioka

N Nagata

Y Takahashi

Affiliations

Soon will be listed here.

Abstract

The etiopathogenesis of focal and segmental glomerular sclerosis (FGS) remains unknown. Using a new animal model for FGS (FGS mouse), we demonstrate here that bone marrow transplantation from normal mice to FGS mice with a high grade of proteinuria (+ + +) ameliorates FGS, and that the transplantation of bone marrow cells or purified hemopoietic stem cells (HSCs) from FGS mice induces FGS in normal mice. These findings strongly suggest that FGS is a stem cell disorder; the abnormalities may be genetically programmed at the level of HSCs.

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