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(NZW X BXSB)F1 Mouse. A New Animal Model of Idiopathic Thrombocytopenic Purpura

Overview
Journal J Exp Med
Specialties Allergy & Immunology
General Medicine
Date 1988 Jun 1
PMID 3290385
Citations 22
Authors
N Oyaizu
R Yasumizu
S Nomura
H Yoshida
S Miyawaki
Y Shibata
S Mitsuoka
K Yasunaga
S Morii
Affiliations
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Abstract

A decrease in thrombocyte count was observed in (NZW x BXSB)F1 (W/B F1) mice at the age of greater than 5 mo, whereas megakaryocyte counts were found to increase in such mice. FACS analyses revealed the presence of both platelet-associated antibodies (PAA) and circulating antiplatelet antibodies. There is a correlation between the presence of these antibodies and the degree of thrombocytopenia. The transplantation of normal bone marrow cells from BALB/c nu/nu mice to W/B F1 mice was found to have preventative and curative effects on thrombocytopenia; the mice showed normal platelet counts and no evidence of circulating antiplatelet antibodies. These results indicate that thrombocytopenia in W/B F1 mice is due to the presence of antibodies to platelets. We therefore think that W/B F1 mice serve as a useful animal model of idiopathic thrombocytopenic purpura (ITP) not only for elucidating the mechanism of the development of antiplatelet antibodies, but also for characterizing autoantibodies to platelets.

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Differences between newborn and adult mice in their response to immune thrombocytopenia.

Hu Z, Slayton W, Rimsza L, Bailey M, Sallmon H, Sola-Visner M Neonatology. 2010; 98(1):100-8.

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