Stem/progenitor Cell in Kidney: Characteristics, Homing, Coordination, and Maintenance

Overview

Journal Stem Cell Res Ther

Publisher Biomed Central

Date 2021 Mar 21

PMID 33743826

Citations 19

Authors

Jiewu Huang

Yaozhong Kong

Chao Xie

Lili Zhou

Affiliations

Soon will be listed here.

Abstract

Renal failure has a high prevalence and is becoming a public health problem worldwide. However, the renal replacement therapies such as dialysis are not yet satisfactory for its multiple complications. While stem/progenitor cell-mediated tissue repair and regenerative medicine show there is light at the end of tunnel. Hence, a better understanding of the characteristics of stem/progenitor cells in kidney and their homing capacity would greatly promote the development of stem cell research and therapy in the kidney field and open a new route to explore new strategies of kidney protection. In this review, we generally summarize the main stem/progenitor cells derived from kidney in situ or originating from the circulation, especially bone marrow. We also elaborate on the kidney-specific microenvironment that allows stem/progenitor cell growth and chemotaxis, and comment on their interaction. Finally, we highlight potential strategies for improving the therapeutic effects of stem/progenitor cell-based therapy. Our review provides important clues to better understand and control the growth of stem cells in kidneys and develop new therapeutic strategies.

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