Localization of Heparin-binding EGF-like Growth Factor in the Smooth Muscle Cells and Macrophages of Human Atherosclerotic Plaques

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1995 Jan 1

PMID 7814641

Citations 34

Authors

J Miyagawa

S Higashiyama

S Kawata

Y Inui

S Tamura

K Yamamoto

M Nishida

T Nakamura

S Yamashita

Y Matsuzawa

Affiliations

Soon will be listed here.

Abstract

Heparin-binding EGF-like growth factor (HB-EGF) is a potent chemoattractant and mitogen for smooth muscle cells (SMC) in culture. To elucidate whether HB-EGF is implicated in the pathogenesis of human atherosclerosis, we examined immunohistochemical localization of HB-EGF in human aortic walls and atherosclerotic plaques. The medial SMC of the aorta in babies and children synthesized HB-EGF protein, while the number of SMC producing HB-EGF was dramatically decreased in young and middle-aged adults. In atherosclerotic plaques, however, marked production of HB-EGF protein was detected in SMC and macrophages of the plaques. Furthermore, EGF receptors, to which HB-EGF is known to bind, were detected in plaque SMC. These data suggest that HB-EGF may be implicated in the migration and proliferation of SMC that occurs in the normal development of arterial walls, and in the formation of atherosclerotic plaques.

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