Platelet-derived Growth Factor MRNA Detection in Human Atherosclerotic Plaques by in Situ Hybridization

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1988 Sep 1

PMID 2843568

Citations 112

Authors

J N Wilcox

K M Smith

L T Williams

S M Schwartz

D Gordon

Affiliations

Soon will be listed here.

Abstract

Platelet-derived growth factor (PDGF) mRNA, and mRNA for its receptor, have been localized to specific cell types within the human atherosclerotic plaque, using in situ hybridization. The predominant cell types found to express PDGF A and B chain mRNA are mesenchymal-appearing intimal cells and endothelial cells, respectively, with little or no expression detected in macrophages. The distribution of PDGF receptor mRNA containing cells was also examined and found to be localized predominantly in the plaque intima.

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