A Heparin-binding Growth Factor Secreted by Macrophage-like Cells That is Related to EGF

Overview

Journal Science

Specialty Science

Date 1991 Feb 22

PMID 1840698

Citations 275

Authors

S Higashiyama

J A Abraham

J Miller

J C Fiddes

M Klagsbrun

Affiliations

Soon will be listed here.

Abstract

Macrophage-like U-937 cells secrete a 22-kilodalton heparin-binding growth factor that is mitogenic for BALB-3T3 fibroblasts and smooth muscle cells, but not endothelial cells. The amino acid sequence predicted from complementary DNA clones indicates that the mitogen is a new member of the epidermal growth factor (EGF) family. This heparin-binding EGF-like growth factor (HB-EGF) binds to EGF receptors on A-431 epidermoid carcinoma cells and smooth muscle cells, but is a far more potent mitogen for smooth muscle cells than is EGF. HB-EGF is also expressed in cultured human macrophages and may be involved in macrophage-mediated cellular proliferation.

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