Susceptibility to Tumors Induced by Polyoma Virus is Conferred by an Endogenous Mouse Mammary Tumor Virus Superantigen

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1995 May 1

PMID 7722447

Citations 34

Authors

A E Lukacher

Y Ma

J P Carroll

J C Laning

M E Dorf

T L BENJAMIN

Affiliations

Soon will be listed here.

Abstract

A dominant gene carried in certain inbred mouse strains confers susceptibility to tumors induced by polyoma virus. This gene, designated Pyvs, was defined in crosses between the highly susceptible C3H/BiDa strain and the highly resistant but H-2k-identical C57BR/cdJ strain. The resistance of C57BR/cdJ mice is overcome by irradiation, indicating an immunological basis. In F1 x C57BR/cdJ backcross mice, tumor susceptibility cosegregates with Mtv-7, a mouse mammary tumor provirus carried by the C3H/BiDa strain. This suggests that Pyvs might encode the Mtv-7 superantigen (SAG) and abrogate polyoma tumor immunosurveillance through elimination of T cells bearing specific V beta domains. DNA typing of 110 backcross mice showed no evidence of recombination between Pyvs and Mtv-7. Strongly biased usage of V beta 6 by polyoma virus-specific CD8+ cytotoxic T lymphocytes in C57BR/cdJ mice implicates T cells bearing this Mtv-7 SAG-reactive V beta domain as critical anti-polyoma tumor effector cells in vivo. These results indicate identity between Pyvs and Mtv-7 sag, and demonstrate a novel mechanism of inherited susceptibility to virus-induced tumors based on effects of an endogenous superantigen on the host's T cell repertoire.

Citing Articles

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Understanding polyomavirus CNS disease - a perspective from mouse models.

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Type I Interferons Regulate the Magnitude and Functionality of Mouse Polyomavirus-Specific CD8 T Cells in a Virus Strain-Dependent Manner.

Qin Q, Shwetank , Frost E, Maru S, Lukacher A J Virol. 2016; 90(10):5187-99.

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Endogenous mouse mammary tumor viruses (mtv): new roles for an old virus in cancer, infection, and immunity.

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PMID: 24324930 PMC: 3840357. DOI: 10.3389/fonc.2013.00287.

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