Stimulation with Specific Antigen Can Block Superantigen-mediated Deletion of T Cells in Vivo

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1994 Mar 15

PMID 8134353

Citations 13

Authors

J E McCormack

J Kappler

P Marrack

Affiliations

Soon will be listed here.

Abstract

The T-cell response to pigeon cytochrome c peptide, residues 88-104 (pcytC), in B10.BR mice is mediated largely by cells bearing both V beta 3 and V alpha 11 variable regions of the T-cell antigen receptor. These cells are, therefore, reactive with the superantigen staphylococcal enterotoxin A (SEA). Recent reports have shown that in vivo exposure to superantigen can lead to deletion of superantigen-reactive T cells from the pool of mature T cells in the periphery. Here we show that upon cotreatment of animals with both SEA and pcytC, bulk deletion of the population of SEA-reactive cells is maintained, while the subpopulation of SEA-reactive T cells that also responds to pcytC is not deleted but instead proliferates in response to pcytC. These results are discussed with regard to mechanisms regulating the balance between T-cell tolerance and T-cell activation in vivo.

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