Cimetidine Impairs Elimination of Chlordiazepoxide (Librium) in Man

Overview

Journal Ann Intern Med

Specialty General Medicine

Date 1980 Aug 1

PMID 7406377

Citations 55

Authors

P V Desmond

R V Patwardhan

S Schenker

K V Speeg Jr

Affiliations

Soon will be listed here.

Abstract

We have studied chlordiazepoxide (Librium) disposition and elimination in eight normal subjects before and after 1 week of cimetidine therapy, 300 mg orally four times a day. Cimetidine strikingly impaired the clearance of chlordiazepoxide from plasma, and this was, at least in part, due to decreased demethylation of the drug to N-desmethylchlordiazepoxide. Since the volume of distribution of chlordiazepoxide was not altered by cimetidine, the elimination half-life of chlordiazepoxide was also significantly prolonged by cimetidine therapy.

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