Lack of Effect of Cimetidine on Action of Phenprocoumon

Overview

Journal Eur J Clin Pharmacol

Specialty Pharmacology

Date 1982 Oct 1

PMID 7173307

Citations 6

Authors

J Harenberg

R Zimmermann

C Staiger

J X de Vries

E Walter

E Weber

Affiliations

Soon will be listed here.

Abstract

In patients on oral warfarin, nicoumalone and phenindione an increase in the anticoagulant effect has been described during concomitant treatment with cimetidine. Therefore the effect of cimetidine on the steady state dynamics of phenprocoumon has been investigated in ten outpatients. No change in the anticoagulant effect of phenprocoumon was observed during or after two weeks on cimetidine, as measured by the thrombotest coagulation method, prothrombin time, fibrinopeptide A concentration and plasma phenprocoumon level. The data show that cimetidine does not interact with the metabolism of phenprocoumon in contrast to warfarin. Thus, phenprocoumon maintenance therapy when combined with concomitant cimetidine treatment can be considered not to carry an increased risk of haemorrhagic complications.

Citing Articles

Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol.

Ufer M Clin Pharmacokinet. 2005; 44(12):1227-46.

PMID: 16372822 DOI: 10.2165/00003088-200544120-00003.

Identification of cytochromes P450 2C9 and 3A4 as the major catalysts of phenprocoumon hydroxylation in vitro.

Ufer M, Svensson J, Krausz K, Gelboin H, Rane A, Tybring G Eur J Clin Pharmacol. 2004; 60(3):173-82.

PMID: 15054565 DOI: 10.1007/s00228-004-0740-5.

Clinically important drug interactions with anticoagulants. An update.

Harder S, Thurmann P Clin Pharmacokinet. 1996; 30(6):416-44.

PMID: 8792056 DOI: 10.2165/00003088-199630060-00002.

Pharmacokinetic interactions of cimetidine 1987.

Somogyi A, Muirhead M Clin Pharmacokinet. 1987; 12(5):321-66.

PMID: 3301148 DOI: 10.2165/00003088-198712050-00002.

The effects of frusemide and probenecid on the pharmacokinetics of phenprocoumon.

Monig H, Bohm M, Ohnhaus E, Kirch W Eur J Clin Pharmacol. 1990; 39(3):261-5.

PMID: 2257863 DOI: 10.1007/BF00315107.

References

Klotz U, Reimann I . Delayed clearance of diazepam due to cimetidine. N Engl J Med. 1980; 302(18):1012-4. DOI: 10.1056/NEJM198005013021807. View

Desmond P, Patwardhan R, Parker R, Schenker S, Speeg Jr K . Effect of cimetidine and other antihistaminics on the elimination of aminopyrine, phenacetin and caffeine. Life Sci. 1980; 26(15):1261-8. DOI: 10.1016/0024-3205(80)90071-5. View

Harenberg J, Hepp G, Schmidt-Gayk H . Fibrinopeptide A in human plasma--evaluation of a new radioimmunoassay technique on microliter--plates. Thromb Res. 1979; 15(3-4):513-22. DOI: 10.1016/0049-3848(79)90157-9. View

Patwardhan R, Yarborough G, Desmond P, Johnson R, Schenker S, Speeg Jr K . Cimetidine spares the glucuronidation of lorazepam and oxazepam. Gastroenterology. 1980; 79(5 Pt 1):912-6. View

Nossel H, Ti M, Kaplan K, Spanondis K, Soland T, Butler Jr V . The generation of fibrinopeptide A in clinical blood samples: evidence for thrombin activity. J Clin Invest. 1976; 58(5):1136-44. PMC: 333281. DOI: 10.1172/JCI108566. View

Pohl L, Haddock R, TRAGER W . Biotransformation of phenprocoumon in the rat. J Med Chem. 1975; 18(5):519-23. View

Hetzel D, Bochner F, Hallpike J, Shearman D, Hann C . Cimetidine interaction with phenytoin. Br Med J (Clin Res Ed). 1981; 282(6275):1512. PMC: 1505456. DOI: 10.1136/bmj.282.6275.1512. View

Klotz U, Reimann I . Influence of cimetidine on the pharmacokinetics of desmethyldiazepam and oxazepam. Eur J Clin Pharmacol. 1980; 18(6):517-20. DOI: 10.1007/BF00874666. View

Clauss A . [Rapid physiological coagulation method in determination of fibrinogen]. Acta Haematol. 1957; 17(4):237-46. DOI: 10.1159/000205234. View

10.

Harenberg J, Haas R, Zimmermann R . Measurement of fibrinopeptide A in patients treated with phenprocoumon. Thromb Haemost. 1981; 45(3):282-4. View

11.

Serlin M, Sibeon R, Mossman S, Breckenridge A, Williams J, Atwood J . Cimetidine: interaction with oral anticoagulants in man. Lancet. 1979; 2(8138):317-9. DOI: 10.1016/s0140-6736(79)90340-4. View

12.

Flind A . Cimetidine and oral anticoagulants. Br Med J. 1978; 2(6148):1367. PMC: 1608456. DOI: 10.1136/bmj.2.6148.1367-a. View

13.

Heni N, GLOGNER P . Pharmacokinetics of phenprocoumon in man investigated using a gas chromatographic method of drug analysis. Naunyn Schmiedebergs Arch Pharmacol. 1976; 293(2):183-6. DOI: 10.1007/BF00499225. View

14.

Wheeler C, TRAGER W, Porter W . Stereochemical aspects of the metabolism of phenprocoumon in rat liver microsomes. Biochem Pharmacol. 1981; 30(13):1785-90. DOI: 10.1016/0006-2952(81)90011-3. View

15.

Owren P . Thrombotest. A new method for controlling anticoagulant therapy. Lancet. 1959; 2(7106):754-8. DOI: 10.1016/s0140-6736(59)90857-8. View

16.

de Vries J, Harenberg J, Walter E, Zimmermann R, Simon M . Determination of the anticoagulant phenprocoumon in human plasma and urine by high-performance liquid chromatography. J Chromatogr. 1982; 231(1):83-92. DOI: 10.1016/s0378-4347(00)80511-3. View

17.

Desmond P, Patwardhan R, Schenker S, Speeg Jr K . Cimetidine impairs elimination of chlordiazepoxide (Librium) in man. Ann Intern Med. 1980; 93(2):266-8. DOI: 10.7326/0003-4819-93-2-266. View

18.

Campbell M, Plachetka J, Jackson J, Moon J, FINLEY P . Cimetidine decreases theophylline clearance. Ann Intern Med. 1981; 95(1):68-9. DOI: 10.7326/0003-4819-95-1-68. View

19.

Zimmermann R, Hoffrichter A, Walter E, Ehlers W, Andrassy K, Lang P . [Oral anticoagulants and platelet function in hypolipemic therapy using a new clofibrate analog (BM 15.075) (author's transl)]. Dtsch Med Wochenschr. 1977; 102(14):509-12. DOI: 10.1055/s-0028-1104921. View

20.

Daneshmend T, Roberts C . Cimetidine and bioavailability of labetalol. Lancet. 1981; 1(8219):565. DOI: 10.1016/s0140-6736(81)92903-2. View