Cimetidine and Prolonged Post-operative Somnolence

Overview

Journal Can Anaesth Soc J

Specialty Anesthesiology

Date 1981 Sep 1

PMID 7284887

Citations 4

Authors

A M Lam

J A Parkin

Affiliations

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Abstract

A case of prolonged post-operative somnolence is described. The patient was on concurrent benzodiazepine and cimetidine therapy. Cimetidine can cause impairment of metabolism of the benzodiazepines by inhibiting the hepatic microsomal enzyme system and its possible role in causing the prolonged somnolence is discussed.

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References

Klotz U, Reimann I . Delayed clearance of diazepam due to cimetidine. N Engl J Med. 1980; 302(18):1012-4. DOI: 10.1056/NEJM198005013021807. View

Coombs D, Hooper D, Colton T . Acid-aspiration prophylaxis by use of preoperative oral administration of cimetidine. Anesthesiology. 1979; 51(4):352-6. DOI: 10.1097/00000542-197910000-00018. View

Pickering B, Palahniuk R, Cumming M . Cimetidine premedication in elective caesarean section. Can Anaesth Soc J. 1980; 27(1):33-5. DOI: 10.1007/BF03006845. View

Bain J, Spoerel W . A streamlined anaesthetic system. Can Anaesth Soc J. 1972; 19(4):426-35. DOI: 10.1007/BF03005967. View

Coombs D, Hooper D . Cimetidine as a prophylactic against acid aspiration at tracheal extubation. Can Anaesth Soc J. 1981; 28(1):33-8. DOI: 10.1007/BF03007287. View

Coombs D, Hooper D, Colton T . Pre-anesthetic cimetidine alteration of gastric fluid volume and pH. Anesth Analg. 1979; 58(3):183-8. DOI: 10.1213/00000539-197905000-00005. View

Van Thiel D, Gavaler J, Smith Jr W, Paul G . Hypothalamic-pituitary-gonadal dysfunction in men using cimetidine. N Engl J Med. 1979; 300(18):1012-5. DOI: 10.1056/NEJM197905033001803. View

Serlin M, Sibeon R, Mossman S, Breckenridge A, Williams J, Atwood J . Cimetidine: interaction with oral anticoagulants in man. Lancet. 1979; 2(8138):317-9. DOI: 10.1016/s0140-6736(79)90340-4. View

Puurunen J, Pelkonen O . Cimetidine inhibits microsomal drug metabolism in the rat. Eur J Pharmacol. 1979; 55(3):335-6. DOI: 10.1016/0014-2999(79)90205-x. View

10.

Schentag J, Cerra F, Calleri G, DeGlopper E, Rose J, Bernhard H . Pharmacokinetic and clinical studies in patients with cimetidine-associated mental confusion. Lancet. 1979; 1(8109):177-81. DOI: 10.1016/s0140-6736(79)90578-6. View

11.

Ruffalo R, Thompson J . Effect of cimetidine on the clearance of benzodiazepines. N Engl J Med. 1980; 303(13):753-4. DOI: 10.1056/NEJM198009253031311. View

12.

Melmon K, Nierenberg D . Drug interactions and the prepared observer. N Engl J Med. 1981; 304(12):723-5. DOI: 10.1056/NEJM198103193041208. View

13.

Ali H, Savarese J . Monitoring of neuromuscular function. Anesthesiology. 1976; 45(2):216-49. DOI: 10.1097/00000542-197608000-00009. View

14.

Foulkes E, Jenkins L . A comparative evaluation of cimetidine and sodium citrate to decrease gastric acidity: effectiveness at the time of induction of anaesthesia. Can Anaesth Soc J. 1981; 28(1):29-32. DOI: 10.1007/BF03007286. View

15.

Feely J, Wilkinson G, Wood A . Reduction of liver blood flow and propranolol metabolism by cimetidine. N Engl J Med. 1981; 304(12):692-5. DOI: 10.1056/NEJM198103193041202. View

16.

Desmond P, Patwardhan R, Schenker S, Speeg Jr K . Cimetidine impairs elimination of chlordiazepoxide (Librium) in man. Ann Intern Med. 1980; 93(2):266-8. DOI: 10.7326/0003-4819-93-2-266. View

17.

Klotz S, KAY B . Cimetidine and Agranulocytosis. Ann Intern Med. 1978; 88(4):579-80. DOI: 10.7326/0003-4819-88-4-579_2. View

18.

Posnett D, Stein R, Graber S, Krantz S . Cimetidine-induced neutropenia: a possible dose-related phenomenon. Arch Intern Med. 1979; 139(5):584-6. View