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Influence of Cimetidine on Pharmacokinetics of Propranolol

Overview
Journal Br Med J (Clin Res Ed)
Specialty General Medicine
Date 1981 Jun 13
PMID 6786672
Citations 39
Authors
A M Heagerty
M A Donovan
C M Castleden
J F POHL
L Patel
A Hedges
Affiliations
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Abstract

Whole-blood propranolol concentrations were estimated for 12 hours after a single 80 mg oral dose was given in six patients taking cimetidine and two weeks after they had stopped the drug. Mean blood propranolol concentrations were higher throughout the sampling period when the patients were taking cimetidine than when they were not, and the difference was statistically significant between one and four hours (p less than 0.05). The mean relative bioavailability of propranolol, measured as the area under the concentration time curve, was significantly higher when the patients were taking cimetidine (p less than 0.025). The mean increase in bioavailability was 136.5 +/- 57.6%, and the results were consistent in each subject. It is concluded from these results that cimetidine reduces the hepatic first-pass extraction of propranolol.

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References
1.
Castleden C, George C, Short M . Contribution of individual differences in gastric emptying to variability in plasma propranolol concentrations. Br J Clin Pharmacol. 1978; 5(2):121-2. PMC: 1429240. DOI: 10.1111/j.1365-2125.1978.tb01610.x. View
2.
Lee R, Osborne P . High-pressure liquid chromatographic determination of cimetidine sulphoxide in human blood and urine. J Chromatogr. 1978; 146(2):354-60. DOI: 10.1016/s0378-4347(00)81903-9. View
3.
Wood A, Kornhauser D, Wilkinson G, SHAND D, Branch R . The influence of cirrhosis on steady-state blood concentrations of unbound propranolol after oral administration. Clin Pharmacokinet. 1978; 3(6):478-87. DOI: 10.2165/00003088-197803060-00005. View
4.
Wood M, SHAND D, Wood A . Altered drug binding due to the use of indwelling heparinized cannulas (heparin lock) for sampling. Clin Pharmacol Ther. 1979; 25(1):103-7. DOI: 10.1002/cpt1979251103. View
5.
Vestal R, Wood A, Branch R, SHAND D, Wilkinson G . Effects of age and cigarette smoking on propranolol disposition. Clin Pharmacol Ther. 1979; 26(1):8-15. DOI: 10.1002/cpt19792618. View