During Lymphatic Regeneration, Precursors for Major Histocompatibility Complex-restricted Cytotoxic T Cells Appear Before Alloreactive Precursors

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1982 Jan 1

PMID 6976415

Citations 2

Authors

M Hurme

M Sihvola

B Bang

Affiliations

Soon will be listed here.

Abstract

Mice were injected with a sublethal dose of cyclophosphamide (Cy) (300 mg/kg), and the appearance of the capacity of the regenerating spleen to form cytotoxic T lymphocytes (CTL) in response against 2,4,6 trinitrophenyl-coupled syngeneic cells or against allogeneic cells was followed. It was found that 8 da after Cy injection, the spleen contained cells that could give rise to CTL, but only 2,4,6 trinitrophenyl-specific CTL responses could be obtained at this stage. A low alloresponse was first seen 2 wk after Cy injection.

Citing Articles

Defective repertoire of proliferative T cells during lymphatic regeneration.

Sihvola M, Hurme M Immunology. 1984; 51(2):313-8.

PMID: 6229475 PMC: 1454444.

Lethal vaccinia infection in cyclophosphamide-suppressed mice is associated with decreased expression of Thy-1, Lyt-2 and L3T4 and diminished IL-2 production in surviving T cells.

Tabi Z, Allan J, Ceredig R, Doherty P Immunology. 1988; 63(3):423-9.

PMID: 2895062 PMC: 1454773.

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