Biological Significance of Alloreactivity: T Cells Stimulated by Sendai Virus-coated Syngeneic Cells Specifically Lyse Allogeneic Target Cells

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1978 Oct 1

PMID 217013

Citations 42

Authors

R Finberg

S J Burakoff

H CANTOR

B Benacerraf

Affiliations

Soon will be listed here.

Abstract

In vitro stimulation of spleen cells from mice immune to Sendai virus results in the generation of effector cells that lyse unmodified allogeneic target cells in addition to syngeneic cells modified by virus. These cells are immunologically specific because their lysis may be blocked by cold targets syngeneic to either the stimulator or the responder. These results support our proposal that the development of alloreactivity can be explained by the crossreactivity between modified self major histocompatibility complex antigens and alloantigens. We propose that exposure to autologous major histocompatibility complex antigens modified by foreign antigens in our environment results in the expansion of the pool of T cells that will respond to alloantigens sharing crossreactive determinants.

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