Intracellular Transport of Cholesterol to the Plasma Membrane

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 1982 Dec 10

PMID 6815192

Citations 38

Authors

R F DeGrella

R D Simoni

Affiliations

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Abstract

We have modified a plasma membrane isolation procedure which utilizes DEAE-Sephadex beads (Gotlib, L. J., and Searls, D. B. (1980) Biochim. Biophys. Acta 602, 207-212) to rapidly measure intracellular transport of cholesterol from the site of synthesis in the endoplasmic reticulum to the plasma membrane. This transport process is rapid, with a half-time of about 10 min, has different kinetics from that of intracellular glycoprotein transport, and appears to be energy-dependent.

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