Intracellular Cholesterol Homeostasis and Amyloid Precursor Protein Processing

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 2010 Mar 23

PMID 20304094

Citations 16

Authors

Mark P Burns

G William Rebeck

Affiliations

Soon will be listed here.

Abstract

Many preclinical and clinical studies have implied a role for cholesterol in the pathogenesis of Alzheimer's disease (AD). In this review we will discuss the movement of intracellular cholesterol and how normal distribution, transport, and export of cholesterol are vital for regulation of the AD related protein, Abeta. We focus on cholesterol distribution in the plasma membrane, transport through the endosomal/lysosomal system, control of cholesterol intracellular signaling at the endoplasmic reticulum and Golgi, the HMG-CoA reductase pathway and finally export of cholesterol from the cell.

Citing Articles

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Chung J, Phukan G, Vergote D, Mohamed A, Maulik M, Stahn M Mol Cell Biol. 2018; 38(11).

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