» Articles » PMID: 20304094

Intracellular Cholesterol Homeostasis and Amyloid Precursor Protein Processing

Overview
Specialties Biochemistry
Biophysics
Date 2010 Mar 23
PMID 20304094
Citations 16
Authors
Affiliations
Soon will be listed here.
Abstract

Many preclinical and clinical studies have implied a role for cholesterol in the pathogenesis of Alzheimer's disease (AD). In this review we will discuss the movement of intracellular cholesterol and how normal distribution, transport, and export of cholesterol are vital for regulation of the AD related protein, Abeta. We focus on cholesterol distribution in the plasma membrane, transport through the endosomal/lysosomal system, control of cholesterol intracellular signaling at the endoplasmic reticulum and Golgi, the HMG-CoA reductase pathway and finally export of cholesterol from the cell.

Citing Articles

Towards a Unitary Hypothesis of Alzheimer's Disease Pathogenesis.

Area-Gomez E, Schon E J Alzheimers Dis. 2024; 98(4):1243-1275.

PMID: 38578892 PMC: 11091651. DOI: 10.3233/JAD-231318.


Flavonoids and fibrate modulate apoE4-induced processing of amyloid precursor protein in neuroblastoma cells.

Davra V, Benzeroual K Front Neurosci. 2024; 17:1245895.

PMID: 38204816 PMC: 10777729. DOI: 10.3389/fnins.2023.1245895.


Preferred Endocytosis of Amyloid Precursor Protein from Cholesterol-Enriched Lipid Raft Microdomains.

Cho Y, Kwon O, Chung S Molecules. 2020; 25(23).

PMID: 33255194 PMC: 7727664. DOI: 10.3390/molecules25235490.


Mechanisms of AMPA Receptor Endosomal Sorting.

Parkinson G, Hanley J Front Mol Neurosci. 2018; 11:440.

PMID: 30568574 PMC: 6289981. DOI: 10.3389/fnmol.2018.00440.


Endosomal-Lysosomal Cholesterol Sequestration by U18666A Differentially Regulates Amyloid Precursor Protein (APP) Metabolism in Normal and APP-Overexpressing Cells.

Chung J, Phukan G, Vergote D, Mohamed A, Maulik M, Stahn M Mol Cell Biol. 2018; 38(11).

PMID: 29530923 PMC: 5954187. DOI: 10.1128/MCB.00529-17.


References
1.
Petanceska S, DeRosa S, Olm V, Diaz N, Sharma A, Duff K . Statin therapy for Alzheimer's disease: will it work?. J Mol Neurosci. 2002; 19(1-2):155-61. DOI: 10.1007/s12031-002-0026-2. View

2.
Hutter-Paier B, Huttunen H, Puglielli L, Eckman C, Kim D, Hofmeister A . The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease. Neuron. 2004; 44(2):227-38. DOI: 10.1016/j.neuron.2004.08.043. View

3.
Zandi P, Sparks D, Khachaturian A, Tschanz J, Norton M, Steinberg M . Do statins reduce risk of incident dementia and Alzheimer disease? The Cache County Study. Arch Gen Psychiatry. 2005; 62(2):217-24. DOI: 10.1001/archpsyc.62.2.217. View

4.
Lala D . The liver X receptors. Curr Opin Investig Drugs. 2005; 6(9):934-43. View

5.
Burns M, Vardanian L, Pajoohesh-Ganji A, Wang L, Cooper M, Harris D . The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo. J Neurochem. 2006; 98(3):792-800. DOI: 10.1111/j.1471-4159.2006.03925.x. View