Membrane Dynamics and Organelle Biogenesis-lipid Pipelines and Vesicular Carriers

Overview

Journal BMC Biol

Publisher Biomed Central

Specialty Biology

Date 2017 Nov 2

PMID 29089042

Citations 40

Authors

Christopher J Stefan

William S Trimble

Sergio Grinstein

Guillaume Drin

Karin Reinisch

Pietro De Camilli

Sarah Cohen

Alex M Valm

Jennifer Lippincott-Schwartz

Tim P Levine

David B Iaea

Frederick R Maxfield

Clare E Futter

Emily R Eden

Delphine Judith

Alexander R van Vliet

Patrizia Agostinis

Sharon A Tooze

Ayumu Sugiura

Heidi M McBride

Affiliations

Soon will be listed here.

Abstract

Discoveries spanning several decades have pointed to vital membrane lipid trafficking pathways involving both vesicular and non-vesicular carriers. But the relative contributions for distinct membrane delivery pathways in cell growth and organelle biogenesis continue to be a puzzle. This is because lipids flow from many sources and across many paths via transport vesicles, non-vesicular transfer proteins, and dynamic interactions between organelles at membrane contact sites. This forum presents our latest understanding, appreciation, and queries regarding the lipid transport mechanisms necessary to drive membrane expansion during organelle biogenesis and cell growth.

Citing Articles

Hoi1 targets the yeast BLTP2 protein to ER-PM contact sites to regulate lipid homeostasis.

Dziurdzik S, Sridhar V, Eng H, Neuman S, Yan J, Davey M bioRxiv. 2025; .

PMID: 39990326 PMC: 11844476. DOI: 10.1101/2025.02.11.637747.

Organelle Interactions in Plant Cells.

Hall M, Kunjumon T, Ghosh P, Currie L, Mathur J Results Probl Cell Differ. 2024; 73:43-69.

PMID: 39242374 DOI: 10.1007/978-3-031-62036-2_3.

Role of isotropic lipid phase in the fusion of photosystem II membranes.

Bode K, Javornik U, Dlouhy O, Zsiros O, Biswas A, Domonkos I Photosynth Res. 2024; 161(1-2):127-140.

PMID: 38662326 PMC: 11269484. DOI: 10.1007/s11120-024-01097-3.

Viral regulation of organelle membrane contact sites.

Hofstadter W, Tsopurashvili E, Cristea I PLoS Biol. 2024; 22(3):e3002529.

PMID: 38442090 PMC: 10914265. DOI: 10.1371/journal.pbio.3002529.

Reconstitution of ORP-mediated lipid exchange coupled to PI4P metabolism.

Fuggetta N, Rigolli N, Magdeleine M, Hamai A, Seminara A, Drin G Proc Natl Acad Sci U S A. 2024; 121(10):e2315493121.

PMID: 38408242 PMC: 10927502. DOI: 10.1073/pnas.2315493121.

References

Allison R, Edgar J, Pearson G, Rizo T, Newton T, Gunther S . Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia. J Cell Biol. 2017; 216(5):1337-1355. PMC: 5412567. DOI: 10.1083/jcb.201609033. View

Clark B . The mammalian START domain protein family in lipid transport in health and disease. J Endocrinol. 2011; 212(3):257-75. DOI: 10.1530/JOE-11-0313. View

Stuible M, Abella J, Feldhammer M, Nossov M, Sangwan V, Blagoev B . PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2. J Biol Chem. 2010; 285(31):23899-907. PMC: 2911340. DOI: 10.1074/jbc.M110.115295. View

David C, Koch J, Oeljeklaus S, Laernsack A, Melchior S, Wiese S . A combined approach of quantitative interaction proteomics and live-cell imaging reveals a regulatory role for endoplasmic reticulum (ER) reticulon homology proteins in peroxisome biogenesis. Mol Cell Proteomics. 2013; 12(9):2408-25. PMC: 3769320. DOI: 10.1074/mcp.M112.017830. View

Hua R, Cheng D, Coyaud E, Freeman S, Di Pietro E, Wang Y . VAPs and ACBD5 tether peroxisomes to the ER for peroxisome maintenance and lipid homeostasis. J Cell Biol. 2017; 216(2):367-377. PMC: 5294787. DOI: 10.1083/jcb.201608128. View

Agrawal G, Subramani S . De novo peroxisome biogenesis: Evolving concepts and conundrums. Biochim Biophys Acta. 2015; 1863(5):892-901. PMC: 4791208. DOI: 10.1016/j.bbamcr.2015.09.014. View

Lees J, Messa M, Sun E, Wheeler H, Torta F, Wenk M . Lipid transport by TMEM24 at ER-plasma membrane contacts regulates pulsatile insulin secretion. Science. 2017; 355(6326). PMC: 5414417. DOI: 10.1126/science.aah6171. View

Kopec K, Alva V, Lupas A . Homology of SMP domains to the TULIP superfamily of lipid-binding proteins provides a structural basis for lipid exchange between ER and mitochondria. Bioinformatics. 2010; 26(16):1927-31. PMC: 2916718. DOI: 10.1093/bioinformatics/btq326. View

Dooley H, Razi M, Polson H, Girardin S, Wilson M, Tooze S . WIPI2 links LC3 conjugation with PI3P, autophagosome formation, and pathogen clearance by recruiting Atg12-5-16L1. Mol Cell. 2014; 55(2):238-52. PMC: 4104028. DOI: 10.1016/j.molcel.2014.05.021. View

10.

Wagner W, Brenowitz S, Hammer 3rd J . Myosin-Va transports the endoplasmic reticulum into the dendritic spines of Purkinje neurons. Nat Cell Biol. 2010; 13(1):40-8. PMC: 3403743. DOI: 10.1038/ncb2132. View

11.

Hamasaki M, Furuta N, Matsuda A, Nezu A, Yamamoto A, Fujita N . Autophagosomes form at ER-mitochondria contact sites. Nature. 2013; 495(7441):389-93. DOI: 10.1038/nature11910. View

12.

Burman C, Ktistakis N . Regulation of autophagy by phosphatidylinositol 3-phosphate. FEBS Lett. 2010; 584(7):1302-12. DOI: 10.1016/j.febslet.2010.01.011. View

13.

Binns D, Januszewski T, Chen Y, Hill J, Markin V, Zhao Y . An intimate collaboration between peroxisomes and lipid bodies. J Cell Biol. 2006; 173(5):719-31. PMC: 2063889. DOI: 10.1083/jcb.200511125. View

14.

Ejsing C, Sampaio J, Surendranath V, Duchoslav E, Ekroos K, Klemm R . Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry. Proc Natl Acad Sci U S A. 2009; 106(7):2136-41. PMC: 2650121. DOI: 10.1073/pnas.0811700106. View

15.

Bajno L, Peng X, Schreiber A, Moore H, Trimble W, Grinstein S . Focal exocytosis of VAMP3-containing vesicles at sites of phagosome formation. J Cell Biol. 2000; 149(3):697-706. PMC: 2174839. DOI: 10.1083/jcb.149.3.697. View

16.

Wanders R . Peroxisomes in human health and disease: metabolic pathways, metabolite transport, interplay with other organelles and signal transduction. Subcell Biochem. 2013; 69:23-44. DOI: 10.1007/978-94-007-6889-5_2. View

17.

Czibener C, Sherer N, Becker S, Pypaert M, Hui E, Chapman E . Ca2+ and synaptotagmin VII-dependent delivery of lysosomal membrane to nascent phagosomes. J Cell Biol. 2006; 174(7):997-1007. PMC: 2064391. DOI: 10.1083/jcb.200605004. View

18.

Kilpatrick B, Yates E, Grimm C, Schapira A, Patel S . Endo-lysosomal TRP mucolipin-1 channels trigger global ER Ca2+ release and Ca2+ influx. J Cell Sci. 2016; 129(20):3859-3867. PMC: 5087663. DOI: 10.1242/jcs.190322. View

19.

AhYoung A, Jiang J, Zhang J, Khoi Dang X, Loo J, Zhou Z . Conserved SMP domains of the ERMES complex bind phospholipids and mediate tether assembly. Proc Natl Acad Sci U S A. 2015; 112(25):E3179-88. PMC: 4485115. DOI: 10.1073/pnas.1422363112. View

20.

Franzini-Armstrong C . STUDIES OF THE TRIAD : I. Structure of the Junction in Frog Twitch Fibers. J Cell Biol. 2009; 47(2):488-99. PMC: 2108094. DOI: 10.1083/jcb.47.2.488. View