Characterization of Sarcomeric Myosin Heavy Chain Genes

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 1983 Jan 10

PMID 6294119

Citations 37

Authors

R M Wydro

H T Nguyen

R M Gubits

B Nadal-Ginard

Affiliations

Soon will be listed here.

Abstract

Myosin heavy chain is encoded by a large multigene family. Using pMHC-25, a recombinant cDNA clone isolated from the rat myogenic cell line L6E9, four members of this family in the rat have been isolated and shown to be tissue-specific and developmentally regulated. The coding regions of these genes share regions of homology interspaced with regions of non-homology. Detailed analysis of one embryonic and one adult myosin heavy chain gene shows that the coding sequences are interrupted by numerous intervening sequences whose number, size, and distribution do not appear to be conserved in the same organism or between species.

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