Inhibition of a Common Human Anti-hepatitis B Surface Antigen Idiotype by a Cyclic Synthetic Peptide

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 1983 May 1

PMID 6188865

Citations 3

Authors

R C Kennedy

G R Dreesman

J T Sparrow

A R Culwell

Y Sanchez

F B Hollinger

J L Melnick

Affiliations

Soon will be listed here.

Abstract

A common human anti-hepatitis B surface antigen idiotype-anti-idiotype reaction was partially inhibited by a cyclic synthetic hepatitis B surface antigen peptide. Reduction of the intrachain disulfide bond and subsequent alkylation destroyed its inhibitory activity, suggesting that a conformation-dependent group alpha epitope was associated with this cyclic peptide.

Citing Articles

Enhancement of the immune response to hepatitis B surface antigen. In vivo administration of antiidiotype induces anti-HBs that expresses a similar idiotype.

Kennedy R, Dreesman G J Exp Med. 1984; 159(3):655-65.

PMID: 6607967 PMC: 2187246. DOI: 10.1084/jem.159.3.655.

Hepatitis B virus infection. Current concepts of chronicity and immunity.

VYAS G, Blum H West J Med. 1984; 140(5):754-62.

PMID: 6328774 PMC: 1011082.

Expression of immunogenic epitopes of hepatitis B surface antigen with hybrid flagellin proteins by a vaccine strain of Salmonella.

Wu J, Newton S, Judd A, Stocker B, ROBINSON W Proc Natl Acad Sci U S A. 1989; 86(12):4726-30.

PMID: 2471978 PMC: 287346. DOI: 10.1073/pnas.86.12.4726.

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