Common Idiotypic Determinant Associated with Human Antibodies to Hepatitis B Surface Antigen

Overview

Journal J Immunol

Specialty Allergy & Immunology

Date 1983 Jan 1

PMID 6183357

Citations 21

Authors

R C Kennedy

G R Dreesman

Affiliations

Soon will be listed here.

Abstract

Anti-Id antisera generated to purified anti-HBs isolated from two different individuals recognized a common idiotype. This idiotype was detected in purified anti-Hbs preparations from three individuals and also in anti-HBs-positive sera obtained from six hemophilic patients. The ability of both HBsAg and a virus-derived HBsAg native polypeptide to inhibit the idiotype-anti-idiotype reaction suggested that the anti-HBs idiotype was associated with the antibody-combining site.

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Idiotypic cross-reactions of monoclonal human lupus autoantibodies.

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