Unusual Human Lymphoma Phenotype Defined by Monoclonal Antibody

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1980 Oct 1

PMID 6158547

Citations 7

Authors

A C Aisenberg

B M Wilkes

Affiliations

Soon will be listed here.

Abstract

The phenotype of three large cell (histiocytic) lymphomas of man has been defined with convential lymphocyte surface marker techniques, a panel of monoclonal antisera of hybridoma derivation (Ortho Pharmaceutical Corp.), and the fluorescence microscope. Two tumors exhibited surface IgG of lambda light-chain type, whereas the third was negative for surface Ig but contained the same Ig in the cytoplasm. With the monoclonal antisera, all three were found to bear two surface antigens (OKT9 and OKT10) previously described on early thymocytes, and were devoid of the Ia antigen. The available knowledge suggests that these neoplasms represent the expansion of a clone of B lymphocytes along the pathway that leads to plasma cell differentiation rather than a clone with both B and T surface membrane markers.

Citing Articles

Immunotherapies targeting CD38 in Multiple Myeloma.

Atanackovic D, Steinbach M, Radhakrishnan S, Luetkens T Oncoimmunology. 2016; 5(11):e1217374.

PMID: 27999737 PMC: 5139636. DOI: 10.1080/2162402X.2016.1217374.

Tumor cell line characterization of a malignant histiocytosis transplanted into nude mice.

Rousseau-Merck M, Jaubert F, Bach M, Niaudet P, Cottreau D, NEZELOF C Virchows Arch A Pathol Anat Histol. 1982; 397(2):171-81.

PMID: 7179735 DOI: 10.1007/BF00442387.

Human T-cell malignancies: Correlative clinical, histopathologic, immunologic, and cytochemical analysis of 23 cases.

Knowles 2nd D, Halper J Am J Pathol. 1982; 106(2):187-203.

PMID: 6978074 PMC: 1916190.

Malignant lymphoma with dual B and T cell markers. Analysis of the neoplastic cells with monoclonal antibodies directed against T cell subsets.

Aisenberg A, BLOCH K, Wilkes B J Exp Med. 1981; 154(5):1709-14.

PMID: 6975352 PMC: 2186513. DOI: 10.1084/jem.154.5.1709.

The cellular content of non Hodgkin lymphomas: a comprehensive analysis using monoclonal antibodies and other surface marker techniques.

Habeshaw J, Bailey D, Stansfeld A, Greaves M Br J Cancer. 1983; 47(3):327-51.

PMID: 6338896 PMC: 2011301. DOI: 10.1038/bjc.1983.52.

References

Aisenberg A, BLOCH K . Immunoglobulins on the surface of neoplastic lymphocytes. N Engl J Med. 1972; 287(6):272-6. DOI: 10.1056/NEJM197208102870603. View

Pincus S, Bianco C, NUSSENZWEIG V . Increased proportion of complement-receptor lymphocytes in the peripheral blood of patients with chronic lymphocytic leukemia. Blood. 1972; 40(3):303-10. View

Aisenberg A, BLOCH K, Long J, Colvin R . Reaction of normal human lymphocytes and chronic lymphocytic leukemia cells with an antithymocyte antiserum. Blood. 1973; 41(3):417-23. View

Aisenberg A, Long J, Wilkes B . Chronic lymphocytic leukemia cells: rosette formation and adherence to nylon fiber columns. J Natl Cancer Inst. 1974; 52(1):13-7. DOI: 10.1093/jnci/52.1.13. View

Jaffe E, Shevach E, Frank M, Green I . Leukemic reticuloendotheliosis: presence of a receptor for cytophilic antibody. Am J Med. 1974; 57(1):108-14. DOI: 10.1016/0002-9343(74)90775-x. View

Aisenberg A, Long J . Lymphocyte surface characteristics in malignant lymphoma. Am J Med. 1975; 58(3):300-6. DOI: 10.1016/0002-9343(75)90595-1. View

Winchester R, Wernet P, KUNKEL H, DuPont B, Jersild C, Fu S . Recognition by pregnancy serums of non-HL-A alloantigens selectively expressed on B lymphocytes. J Exp Med. 1975; 141(4):924-9. PMC: 2189757. View

Schlossman S, Chess L, Humphreys R, Strominger J . Distribution of Ia-like molecules on the surface of normal and leukemic human cells. Proc Natl Acad Sci U S A. 1976; 73(4):1288-92. PMC: 430249. DOI: 10.1073/pnas.73.4.1288. View

Aisenberg A, Wilkes B . Lymphosarcoma cell leukemia: the contribution of cell surface study to diagnosis. Blood. 1976; 48(5):707-15. View

10.

Greenberg R, Mathieson B, CAMPBELL P, Zatz M . Multiple occurrence of spontaneous AKR/J lymphomas with T and B cell characteristics. J Immunol. 1977; 118(4):1181-90. View

11.

Halper J, Fu S, Wang C, Winchester R, KUNKEL H . Patterns of expression of human "Ia-like" antigens during the terminal stages of B cell development. J Immunol. 1978; 120(5):1480-4. View

12.

Fu S, Chiorazzi N, Wang C, Montrazeri G, KUNKEL H, Ko H . Ia-bearing T lymphocytes in man. Their identification and role in the generation of allogeneic helper activity. J Exp Med. 1978; 148(5):1423-8. PMC: 2185058. DOI: 10.1084/jem.148.5.1423. View

13.

Reinherz E, Kung P, Goldstein G, Schlossman S . A monoclonal antibody with selective reactivity with functionally mature human thymocytes and all peripheral human T cells. J Immunol. 1979; 123(3):1312-7. View

14.

Reinherz E, Kung P, Goldstein G, Schlossman S . Separation of functional subsets of human T cells by a monoclonal antibody. Proc Natl Acad Sci U S A. 1979; 76(8):4061-5. PMC: 383977. DOI: 10.1073/pnas.76.8.4061. View

15.

McKenzie I, Potter T . Murine lymphocyte surface antigens. Adv Immunol. 1979; 27:179-338. DOI: 10.1016/s0065-2776(08)60263-1. View

16.

Reinherz E, Kung P, Pesando J, Ritz J, Goldstein G, Schlossman S . Ia determinants on human T-cell subsets defined by monoclonal antibody. Activation stimuli required for expression. J Exp Med. 1979; 150(6):1472-82. PMC: 2185738. DOI: 10.1084/jem.150.6.1472. View

17.

Stass S, Schumacher H, Keneklis T, Bollum F . Terminal deoxynucleotidyl transferase immunofluorescence of bone marrow smears: experience in 156 cases. Am J Clin Pathol. 1979; 72(6):898-903. DOI: 10.1093/ajcp/72.6.898. View

18.

Aisenberg A, Wilkes B, Long J, Harris N . Cell surface phenotype in lymphoproliferative disease. Am J Med. 1980; 68(2):206-13. DOI: 10.1016/0002-9343(80)90355-1. View

19.

Breard J, Reinherz E, Kung P, Goldstein G, Schlossman S . A monoclonal antibody reactive with human peripheral blood monocytes. J Immunol. 1980; 124(4):1943-8. View

20.

Winchester R, KUNKEL H . The human Ia system. Adv Immunol. 1979; 28:221-92. View