Localisation of the Becker Muscular Dystrophy Gene on the Short Arm of the X Chromosome by Linkage to Cloned DNA Sequences

Overview

Journal Hum Genet

Specialty Genetics

Date 1984 Jan 1

PMID 6086495

Citations 36

Authors

H M Kingston

M Sarfarazi

N S Thomas

P S Harper

Affiliations

Soon will be listed here.

Abstract

A linkage study in 30 Becker muscular dystrophy (BMD) kindreds using three cloned DNA sequences from the X chromosome which demonstrate restriction fragment length polymorphisms (RFLPs), suggests that the BMD gene is located on the short arm of the X chromosome, in the p21 region. The genes for Becker and Duchenne dystrophies must therefore be closely linked, if not allelic, and any future DNA probes found to be of practical use in one disorder should be equally applicable to the other. The linkage analysis also provides data on the frequency of recombination along the short arm of the X chromosome, and across the centromeric region.

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