Definitive Localization of Becker Muscular Dystrophy in Xp by Linkage to a Cluster of DNA Polymorphisms (DXS43 and DXS9)

Overview

Journal Hum Genet

Specialty Genetics

Date 1985 Jan 1

PMID 2993155

Citations 7

Authors

S Fadda

M Mochi

L Roncuzzi

S Sangiorgi

D Sbarra

M Zatz

G Romeo

Affiliations

Soon will be listed here.

Abstract

A study of linkage between Becker muscular dystrophy and four X chromosome-specific DNA polymorphisms in 17 kindreds has indicated that this gene is located in Xp, as already anticipated by single pedigree analysis. In particular the DXS43 and DXS9 loci, identified by probes D2 and RC8, respectively, are closely linked to each other and are both located at approximately 15 cM from the Becker locus. These linkage data, together with the previously established linkage between Becker and the DXS7 locus identified by probe L 1.28, indicate that the Becker gene is located in the same region where Duchenne has been mapped and also yield information about relative genetic distances among different DNA polymorphisms of the X chromosome.

Citing Articles

Sporadic cases in Duchenne muscular dystrophy. A reappraisal through segregation analysis on 988 sibships.

Russo A, Barbujani G, Mostacciuolo M, Herrmann F, Spiegler A, Galluzzi G Hum Genet. 1987; 76(3):230-5.

PMID: 3596597 DOI: 10.1007/BF00283613.

Atypical form of X-linked proximal pseudohypertrophic muscular dystrophy.

Spiegler A, Hausmanowa-Petrusewicz I, Borkowska J, Herrmann F J Neurol. 1987; 234(3):163-71.

PMID: 3585425 DOI: 10.1007/BF00314137.

Population data on benign and severe forms of X-linked muscular dystrophy.

Mostacciuolo M, Lombardi A, Cambissa V, Danieli G, Angelini C Hum Genet. 1987; 75(3):217-20.

PMID: 3557448 DOI: 10.1007/BF00281062.

Italian experience regarding the prevention of Duchenne and Becker muscular dystrophies.

Romeo G, Devoto M, Archidiacono N, Ferlini A, Roncuzzi L, Melis M Eur J Pediatr. 1988; 147(4):412-5.

PMID: 3165066 DOI: 10.1007/BF00496422.

Genetic linkage study between the loci for Duchenne and Becker muscular dystrophy and nine X-chromosomal DNA markers.

Wilichowski E, Krawczak M, Seemanova E, Hanefeld F, Schmidtke J Hum Genet. 1987; 75(1):32-40.

PMID: 3026946 DOI: 10.1007/BF00273835.

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