Multipoint Linkage Analysis of the Short Arm of the Human X Chromosome in Families with X-linked Muscular Dystrophy

Overview

Journal Hum Genet

Specialty Genetics

Date 1985 Jan 1

PMID 3860471

Citations 14

Authors

D E Wilcox

N A Affara

J R Yates

M A Ferguson-Smith

P L Pearson

Affiliations

Soon will be listed here.

Abstract

Sixteen three generation families from the West of Scotland with Duchenne muscular dystrophy (DMD) or Becker muscular dystrophy (BMD) have been studied using the Xg blood group and seven cloned DNA sequences which recognise DNA polymorphisms on the short arm of the X chromosome (Xp). Linkage has been established between DMD and probe 754 with a maximum lod score (Z) of 4.47 at a recombination fraction (theta) of 0.04. DMD has also been linked to probe 99-6 (Z = 3.75, theta = 0.03). Combining the data in this study with that of previously published work has established linkage between DMD and L1.28 (Z = 4.42, theta = 0.17) and altered the linkage estimate between BMD and L1.28 (Z = 3.50, theta = 0.22). An approximate order for the loci has been deduced by the study of recombinant chromosomes in phase known families informative for three or more loci. The proposed order is centromere--L1.28--754--DMD/BMD--99-6--D2--782--Xg. These results conclusively map both DMD and BMD to the central region of Xp and add weight to the original suggestion that they may be allelic.

Citing Articles

Regional assignment of Y-linked DNA probes by deletion mapping and their homology with X-chromosome and autosomal sequences.

Affara N, Florentin L, Morrison N, Kwok K, Mitchell M, Cook A Nucleic Acids Res. 1986; 14(13):5353-73.

PMID: 3737403 PMC: 311545. DOI: 10.1093/nar/14.13.5353.

Duchenne muscular dystrophy due to familial Xp21 deletion detectable by DNA analysis and flow cytometry.

Wilcox D, Cooke A, Colgan J, Boyd E, Aitken D, Sinclair L Hum Genet. 1986; 73(2):175-80.

PMID: 3721503 DOI: 10.1007/BF00291610.

Mapping the testis determinants by an analysis of Y-specific sequences in males with apparent XX and XO karyotypes and females with XY karyotypes.

Affara N, Ferguson-Smith M, Magenis R, Tolmie J, Boyd E, Cooke A Nucleic Acids Res. 1987; 15(18):7325-42.

PMID: 3658694 PMC: 306251. DOI: 10.1093/nar/15.18.7325.

Atypical form of X-linked proximal pseudohypertrophic muscular dystrophy.

Spiegler A, Hausmanowa-Petrusewicz I, Borkowska J, Herrmann F J Neurol. 1987; 234(3):163-71.

PMID: 3585425 DOI: 10.1007/BF00314137.

A multipoint linkage analysis program for X-linked disorders, with the example of Duchenne muscular dystrophy and seven DNA probes.

Clayton J Hum Genet. 1986; 73(1):68-72.

PMID: 3458666 DOI: 10.1007/BF00292667.

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