Genetic Linkage Relationship Between the Xg Blood Group System and Two X Chromosome DNA Polymorphisms in Families with Duchenne and Becker Muscular Dystrophy

Overview

Journal Hum Genet

Specialty Genetics

Date 1983 Jan 1

PMID 6317539

Citations 5

Authors

M Sarfarazi

P S Harper

H M Kingston

J M Murray

T OBrien

K E Davies

R Williamson

P Tippett

R SANGER

Affiliations

Soon will be listed here.

Abstract

The existence of linkage has been investigated between the Xg blood group system, two DNA restriction fragment length polymorphisms (RFLPs) located on the short arm of the X chromosome, Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). No linkage was found between the Xg locus and the more proximal RFLP (L 1.28); close linkage between Xg and the more distal RFLP (lambda RC8) was also excluded. Both RFLPs show linkage with DMD but are not closely linked with each other. Analyses of 11 families with DMD and ten with BMD, informative for the Xg blood group, reinforce the conclusions of others that there is no measurable linkage between the loci for Xg and for the X-linked forms of muscular dystrophy.

Citing Articles

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Localisation of the Becker muscular dystrophy gene on the short arm of the X chromosome by linkage to cloned DNA sequences.

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Minor Xp21 chromosome deletion in a male associated with expression of Duchenne muscular dystrophy, chronic granulomatous disease, retinitis pigmentosa, and McLeod syndrome.

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Genetic linkage study between the loci for Duchenne and Becker muscular dystrophy and nine X-chromosomal DNA markers.

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