The Distribution of Vasopressin and Oxytocin in the Hypothalamoneurohypophysial System of the Guinea-pig

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1973 Jun 1

PMID 4739050

Citations 8

Authors

G W Bisset

M L Errington

C D Richards

Affiliations

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Abstract

1. The ratio of the content of vasopressin to that of oxytocin (V/O ratio) was estimated in the supraoptic nucleus (SON), paraventricular nucleus (PVN) and posterior pituitary gland (PIT) of guinea-pigs.2. Extracts were assayed for antidiuretic activity to estimate vasopressin and for milk-ejecting activity to estimate oxytocin. In assays for milk-ejecting activity, trypsin was used to inactivate vasopressin in the extracts.3. The mean V/O ratios in the SON, PVN and PIT were 28, 8.5 and 7.0 respectively in male guinea-pigs, 6.8, 7.4 and 6.9 in non-lactating females, and 5.1, 3.3 and 6.6 in lactating females.4. The distribution of the hormones within the hypothalamus is discussed in relation to their independent release in response to electrical stimulation of the SON and PVN.

Citing Articles

A cholinergic link in the reflex release of vasopressin by hypotension in the rat.

Bisset G, Chowdrey H J Physiol. 1984; 354:523-45.

PMID: 6148413 PMC: 1193427. DOI: 10.1113/jphysiol.1984.sp015391.

The relation between the caudo-dorsal region of the preoptic nucleus and the pars nervosa of the pituitary gland in Xenopus lavis tadpoles. An investigation based on hypothalamic lesions.

Notenboom C Cell Tissue Res. 1974; 149(4):457-71.

PMID: 4603144 DOI: 10.1007/BF00223025.

Synthesis of both neurohypophysial hormones in both the paraventricular and supraoptic nuclei of the rat.

Burford G, Dyball R, Moss R, PICKERING B J Anat. 1974; 117(Pt 2):261-9.

PMID: 4461720 PMC: 1231400.

Bioassay of oxytocin on the superfused mammary gland of the mouse, using an automatic apparatus.

Robinson I, Walker J Br J Pharmacol. 1974; 50(3):409-17.

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Central inhibition by gamma-aminobutyric acid and muscimol of the release of vasopressin and oxytocin by an osmotic stimulus in the rat.

Bisset G, Chowdrey H, Fairhall K, Gunn L Br J Pharmacol. 1990; 99(3):529-35.

PMID: 2331582 PMC: 1917349. DOI: 10.1111/j.1476-5381.1990.tb12963.x.

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