Towards Understanding Cancer Dormancy over Strategic Hitching Up Mechanisms to Technologies

Overview

Journal Mol Cancer

Publisher Biomed Central

Specialties Molecular Biology
Oncology

Date 2025 Feb 14

PMID 39953555

Authors

Sumin Yang

Jieun Seo

Jeonghyeon Choi

Sung-Hyun Kim

Yunmin Kuk

Kyung Chan Park

Mingon Kang

Sangwon Byun

Jae-Yeol Joo

Affiliations

Soon will be listed here.

Abstract

Delving into cancer dormancy has been an inherent task that may drive the lethal recurrence of cancer after primary tumor relief. Cells in quiescence can survive for a short or long term in silence, may undergo genetic or epigenetic changes, and can initiate relapse through certain contextual cues. The state of dormancy can be induced by multiple conditions including cancer drug treatment, in turn, undergoes a life cycle that generally occurs through dissemination, invasion, intravasation, circulation, immune evasion, extravasation, and colonization. Throughout this cascade, a cellular machinery governs the fate of individual cells, largely affected by gene regulation. Despite its significance, a precise view of cancer dormancy is yet hampered. Revolutionizing advanced single cell and long read sequencing through analysis methodologies and artificial intelligence, the most recent stage in the research tool progress, is expected to provide a holistic view of the diverse aspects of cancer dormancy.

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