Precision Medicine for Pulmonary Vascular Disease: The Future Is Now (2023 Grover Conference Series)

Overview

Journal Pulm Circ

Publisher Wiley

Specialty Pulmonary Medicine

Date 2025 Jan 3

PMID 39749110

Authors

Lindsay M Forbes

Natalie Bauer

Aritra Bhadra

Harm J Bogaard

Gaurav Choudhary

Kara N Goss

Stefan Graf

Gustavo A Heresi

Rachel K Hopper

Arun Jose

Yunhye Kim

Timothy Klouda

Tim Lahm

Allan Lawrie

Peter J Leary

Jane A Leopold

Suellen D Oliveira

Sasha Z Prisco

Ruslan Rafikov

Christopher J Rhodes

Duncan J Stewart

Rebecca R Vanderpool

Ke Yuan

Alexsandra Zimmer

Anna R Hemnes

Vinicio A de Jesus Perez

Martin R Wilkins

Affiliations

Soon will be listed here.

Abstract

Pulmonary vascular disease is not a single condition; rather it can accompany a variety of pathologies that impact the pulmonary vasculature. Applying precision medicine strategies to better phenotype, diagnose, monitor, and treat pulmonary vascular disease is increasingly possible with the growing accessibility of powerful clinical and research tools. Nevertheless, challenges exist in implementing these tools to optimal effect. The 2023 Grover Conference Series reviewed the research landscape to summarize the current state of the art and provide a better understanding of the application of precision medicine to managing pulmonary vascular disease. In particular, the following aspects were discussed: (1) Clinical phenotypes, (2) genetics, (3) epigenetics, (4) biomarker discovery, (5) application of precision biology to clinical trials, (6) the right ventricle (RV), and (7) integrating precision medicine to clinical care. The present review summarizes the content of these discussions and the prospects for the future.

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