Martin R Wilkins
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Explore the profile of Martin R Wilkins including associated specialties, affiliations and a list of published articles.
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162
Citations
6769
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Recent Articles
1.
Rothman A, Villar S, Middleton J, Roussakis A, Varian F, Zafar H, et al.
Am J Respir Crit Care Med
. 2025 Mar;
PMID: 40080796
Rationale: Imatinib 400mg daily reduces pulmonary vascular resistance and improves exercise capacity in patients with pulmonary arterial hypertension. Concerns about safety and tolerability limit its use. Objectives: To identify a...
2.
Yogeswaran A, Funderich M, Olschewski H, Kovacs G, Kiely D, Lawrie A, et al.
ERJ Open Res
. 2025 Feb;
11(1).
PMID: 40008170
Introduction: The definition of pulmonary hypertension (PH) was recently changed and led to a new subset of PH patients with mildly impaired pulmonary haemodynamics, characterised by a mean pulmonary artery...
3.
Fellows A, Quigley K, Leung V, Ainscough A, Wilkins M, Barnett H, et al.
Br J Pharmacol
. 2025 Feb;
PMID: 39979037
Background And Purpose: Vasoreactivity of pulmonary arteries regulates blood flow through the lungs. Excessive constriction of these vessels contributes to pulmonary arterial hypertension (PAH), a progressive and incurable condition, resulting...
4.
Precision Medicine for Pulmonary Vascular Disease: The Future Is Now (2023 Grover Conference Series)
Forbes L, Bauer N, Bhadra A, Bogaard H, Choudhary G, Goss K, et al.
Pulm Circ
. 2025 Jan;
15(1):e70027.
PMID: 39749110
Pulmonary vascular disease is not a single condition; rather it can accompany a variety of pathologies that impact the pulmonary vasculature. Applying precision medicine strategies to better phenotype, diagnose, monitor,...
5.
Deliu N, Das R, May A, Newman J, Steele J, Duckworth M, et al.
Trials
. 2024 Oct;
25(1):680.
PMID: 39407331
Background: Pulmonary arterial hypertension is a life-threatening progressive disorder characterised by high blood pressure (hypertension) in the arteries of the lungs (pulmonary artery). Although treatable, there is no known cure...
6.
Harbaum L, Hennigs J, Pott J, Ostermann J, Sinning C, Sau A, et al.
Am J Respir Crit Care Med
. 2024 Oct;
PMID: 39374572
Rationale: While sex differences in right heart phenotypes have been observed, the molecular drivers remain unknown. Objectives: To provide biological insights into sex differences in the structure and function of...
7.
Weatherald J, Fleming T, Wilkins M, Cascino T, Psotka M, Zamanian R, et al.
Eur Respir J
. 2024 Aug;
64(4).
PMID: 39209468
Clinical trials in pulmonary arterial hypertension (PAH) have led to the approval of several effective treatments that improve symptoms, exercise capacity and clinical outcomes. In phase 3 clinical trials, primary...
8.
Tello K, Yogeswaran A, Majeed R, Kiely D, Lawrie A, Brittain E, et al.
Chest
. 2024 Aug;
167(1):224-240.
PMID: 39182575
Background: Patients with COPD frequently demonstrate pulmonary hypertension (PH). Severe PH in patients with COPD, identified by pulmonary vascular resistance (PVR) of > 5 Wood units (WU), is closely linked...
9.
Hong J, Medzikovic L, Sun W, Wong B, Ruffenach G, Rhodes C, et al.
Circulation
. 2024 Aug;
150(16):1268-1287.
PMID: 39167456
Background: Integrative multiomics can elucidate pulmonary arterial hypertension (PAH) pathobiology, but procuring human PAH lung samples is rare. Methods: We leveraged transcriptomic profiling and deep phenotyping of the largest multicenter...
10.
Kariotis S, Tan P, Lu H, Rhodes C, Wilkins M, Lawrie A, et al.
Gigascience
. 2024 Jul;
13.
PMID: 38991852
Background: Cohort studies increasingly collect biosamples for molecular profiling and are observing molecular heterogeneity. High-throughput RNA sequencing is providing large datasets capable of reflecting disease mechanisms. Clustering approaches have produced...