Siesta Behavior and Genetics Interact to Influence Obesity Risk

Overview

Journal Obesity (Silver Spring)

Specialties Endocrinology
Nutritional Sciences
Physiology

Date 2024 Dec 23

PMID 39711202

Authors

Maria Rodriguez-Martin

Diego Salmeron

Hassan S Dashti

Ana Isabel Cascales

Aurora Aragon-Alonso

Frank A J L Scheer

Richa Saxena

Marta Garaulet

Affiliations

Soon will be listed here.

Abstract

Objective: In this cross-sectional study, we aim to investigate the interactions between obesity, siesta behavior, and the genetic propensity for siesta in a Mediterranean population, in whom siesta is deeply rooted.

Methods: We applied a previously generated Siesta-Polygenic Score (PGS) in the ONTIME study (n = 1278). Siesta and other Mediterranean lifestyle behaviors were characterized using questionnaires. We further determined obesity grade. Secondarily, we measured weight loss during treatment as well as long-term weight-loss maintenance. Logistic regression analyses were performed to address our aim.

Results: A total of 42.4% of the population usually took siesta. A significant genetic influence on siesta propensity was found, with a higher genetic predisposition linked to taking siesta more frequently (odds ratio [OR] = 1.17, 95% CI: 1.03-1.32; p = 0.015). Participants with a higher genetic propensity for siesta showed poorer dietary habits (p < 0.05). Among individuals with a high genetic propensity for siesta, we found that those who usually take siesta have lower odds of having obesity (p = 0.038) compared with those who do not. Similarly, in exploratory analysis, among individuals with a high genetic propensity for siesta, we found that those who usually take siesta have higher odds of weight-loss success (p = 0.007) compared with those who do not. CONCLUSIONS: Considering the ongoing debate regarding whether siesta is beneficial or detrimental, our findings suggest that individual genetic predisposition to siesta might influence the association between siesta and health.

Citing Articles

Siesta behavior and genetics interact to influence obesity risk.

Rodriguez-Martin M, Salmeron D, Dashti H, Isabel Cascales A, Aragon-Alonso A, Scheer F Obesity (Silver Spring). 2024; 33(1):164-176.

PMID: 39711202 PMC: 11664305. DOI: 10.1002/oby.24173.

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