Genetic Determinants of Daytime Napping and Effects on Cardiometabolic Health

Overview

Journal Nat Commun

Specialty Biology

Date 2021 Feb 11

PMID 33568662

Citations 79

Authors

Hassan S Dashti

Iyas Daghlas

Jacqueline M Lane

Yunru Huang

Miriam S Udler

Heming Wang

Hanna M Ollila

Samuel E Jones

Jaegil Kim

Andrew R Wood

Michael N Weedon

Stella Aslibekyan

Marta Garaulet

Richa Saxena

Affiliations

Soon will be listed here.

Abstract

Daytime napping is a common, heritable behavior, but its genetic basis and causal relationship with cardiometabolic health remain unclear. Here, we perform a genome-wide association study of self-reported daytime napping in the UK Biobank (n = 452,633) and identify 123 loci of which 61 replicate in the 23andMe research cohort (n = 541,333). Findings include missense variants in established drug targets for sleep disorders (HCRTR1, HCRTR2), genes with roles in arousal (TRPC6, PNOC), and genes suggesting an obesity-hypersomnolence pathway (PNOC, PATJ). Association signals are concordant with accelerometer-measured daytime inactivity duration and 33 loci colocalize with loci for other sleep phenotypes. Cluster analysis identifies three distinct clusters of nap-promoting mechanisms with heterogeneous associations with cardiometabolic outcomes. Mendelian randomization shows potential causal links between more frequent daytime napping and higher blood pressure and waist circumference.

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