Synthesis of Hydroxytyrosol Analogs with Enhanced Antioxidant and Cytostatic Properties Against MG-63 Human Osteoblast-like Cells and Their Potential Implications for Bone Health

Overview

Journal Arch Pharm (Weinheim)

Specialty Pharmacy

Date 2024 Nov 16

PMID 39548899

Authors

Eleftheria A Georgiou

Ioanna Kalpaktsi

Katerina Gioti

Maria Choleva

Elizabeth Fragopoulou

Alexios-Leandros Skaltsounis

Roxane Tenta

Ioannis K Kostakis

Affiliations

Soon will be listed here.

Abstract

Sixteen novel hydroxytyrosol (HT) analogs with substitutions at the C-1 position of the HT aliphatic side chain were synthesized and evaluated for their cytostatic activity against MG-63 human osteoblast-like cells and for their antioxidant properties. The results revealed that these analogs exhibited significantly higher inhibitory activity compared with HT, which served as the positive control. Among these, the cyclo-substituted compounds stood out as particularly potent, demonstrating strong radical scavenging abilities and notable cytostatic effects against MG-63 cells. These findings suggest that the cyclo-substituted HT analogs hold considerable promise for the development of novel antioxidants with potential applications in bone physiology.

Citing Articles

Synthesis of hydroxytyrosol analogs with enhanced antioxidant and cytostatic properties against MG-63 human osteoblast-like cells and their potential implications for bone health.

Georgiou E, Kalpaktsi I, Gioti K, Choleva M, Fragopoulou E, Skaltsounis A Arch Pharm (Weinheim). 2024; 358(1):e2400469.

PMID: 39548899 PMC: 11726141. DOI: 10.1002/ardp.202400469.

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