High-throughput Sequencing-based Neutralization Assay Reveals How Repeated Vaccinations Impact Titers to Recent Human H1N1 Influenza Strains

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2024 Sep 24

PMID 39315814

Authors

Andrea N Loes

Rosario Araceli L Tarabi

John Huddleston

Lisa Touyon

Sook San Wong

Samuel M S Cheng

Nancy H L Leung

William W Hannon

Trevor Bedford

Sarah Cobey

Benjamin J Cowling

Jesse D Bloom

Affiliations

Soon will be listed here.

Abstract

Importance: We describe a new approach that can rapidly measure how the antibodies in human serum inhibit infection by many different influenza strains. This new approach is useful for understanding how viral evolution affects antibody immunity. We apply the approach to study the effect of repeated influenza vaccination.

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