Assessment of Humoral Immune Responses to Repeated Influenza Vaccination in a Multiyear Cohort: A 5-Year Follow-up

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2023 Aug 25

PMID 37624957

Authors

Meng-Hsuan Sung

W Zane Billings

Michael A Carlock

Hannah B Hanley

Justin Bahl

Andreas Handel

Ted M Ross

Ye Shen

Affiliations

Soon will be listed here.

Abstract

The long-term effects of host factors on vaccine-elicited immune responses have not been well studied, and the interactions of host factors with annual influenza vaccinations are yet to be explored. We analyzed data from a cohort of 386 individuals who received the standard-dose influenza vaccine and enrolled in ≥2 seasons from 2016 to 2020. Our analyses indicated disparate vaccine-elicited immune responses between males and females in adults when they were repeatedly vaccinated for at least 2 seasons. Notably, we found interactive effects between age and body mass index (BMI) on overall immune responses, and between sex at birth and BMI in adults.

Citing Articles

High-throughput sequencing-based neutralization assay reveals how repeated vaccinations impact titers to recent human H1N1 influenza strains.

Loes A, Tarabi R, Huddleston J, Touyon L, Wong S, Cheng S J Virol. 2024; 98(10):e0068924.

PMID: 39315814 PMC: 11494878. DOI: 10.1128/jvi.00689-24.

High-throughput sequencing-based neutralization assay reveals how repeated vaccinations impact titers to recent human H1N1 influenza strains.

Loes A, Tarabi R, Huddleston J, Touyon L, Wong S, Cheng S bioRxiv. 2024; .

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